Design, Materials, and Mechanobiology of Biodegradable Scaffolds for Bone Tissue Engineering

Velasco, Marco A. De; Narváez-Tovar, Carlos Alberto; Garzón‐Alvarado, Diego Alexander

doi:10.1155/2015/729076

Cited by 325 publications

(235 citation statements)

References 221 publications

(227 reference statements)

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“…According to Velasco et al, the scaffolds with pore size that is close to 350 μm will promote the growth of bone tissue and the desirable pore size range for scaffolds is between 100 μm to 500 μm [9]. Based on Table 2, the overall pore size for all samples was in the range of 130 to 400 μm which is suitable for the bone tissue growth.…”

Section: Sem/edx Analysismentioning

confidence: 94%

Effect of polyurethane (PU) – bioactive glass (BG) ratio on the development of BG reinforced PU scaffold

Lip¹,

Abdullah²,

Zubir³

2016

AIP Conference Proceedings

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Abstract. Nowadays, variety of biomaterials may be used to produce implanted scaffolds such as metal-based, ceramicbased and polymer-based materials. In this study, porous bioactive glass (BG) reinforced polyurethane (PU) composite scaffolds with different PU:BG mass ratio (10 to 40 wt%) were fabricated as a potential candidate for synthetic bone graft. The PU-BG scaffolds were prepared using solvent casting combined with salt leaching (SCPL) method and were subjected to several characterizations including fourier transform infra-red (FTIR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive x-ray spectroscopy (EDX). FTIR spectrum showed the trace of BG particles in the PU-BG scaffolds with high concentration of BG (30 and 40 wt%). EDX confirmed that the white particles in the PU-BG scaffold as observed via SEM micrograph were BG particles. A slightly round and irregular pore structures were observed for the PU-BG scaffolds prepared in this study. More homogeneous pore structures were observed as the amount of BG in the PU-BG scaffold is increased. The overall pore size for all scaffolds was in the range of 130 to 400 μm which is suitable for the growth of bone tissue.

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Section: Sem/edx Analysismentioning

confidence: 94%

Effect of polyurethane (PU) – bioactive glass (BG) ratio on the development of BG reinforced PU scaffold

Lip¹,

Abdullah²,

Zubir³

2016

AIP Conference Proceedings

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“…Gyroid Diamond The maximum compressive strength of the trabecular bone is in the range of 2 to 12MPa [11]. Of the TPMS tested, Schwarz Primitive and Schwarz Diamond have maximum compression strengths, compatible with those of the bone, being Schwarz Primitive the one with the greatest mechanical resistance (4.7MPa).…”

Section: Primitivementioning

confidence: 99%

“…Regarding the mechanical properties of spongy bone tissue, it has been found that its maximum compressive strength is between 2 and 12MPa while its Young's modulus is between 0.02 and 0.5GPa [11].…”

Section: Introductionmentioning

confidence: 99%

Mechanical properties of ceramic structures based on Triply Periodic Minimal Surface (TPMS) processed by 3D printing

Restrepo

Ocampo

Ramírez

et al. 2017

J. Phys.: Conf. Ser.

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Abstract. Repairing tissues and organs has been the main goal of surgical procedures. Since the 1990s, the main goal of tissue engineering has been reparation, using porous scaffolds that serve as a three-dimensional template for the initial fixation of cells and subsequent tissue formation both in vitro and in vivo. A scaffold must have specific characteristics of porosity, interconnectivity, surface area, pore volume, surface tortuosity, permeability and mechanical properties, which makes its design, manufacturing and characterization a complex process. Inspired by nature, triply periodic minimal surfaces (TPMS) have emerged as an alternative for the manufacture of porous pieces with design requirements, such as scaffolds for tissue repair. In the present work, we used the technique of 3D printing to obtain ceramic structures with Gyroid, Schwarz Primitive and Schwarz Diamond Surfaces shapes, three TPMS that fulfil the geometric requirements of a bone tissue scaffold. The main objective of this work is to compare the mechanical properties of ceramic pieces of three different forms of TPMS printed in 3D using a commercial ceramic paste. In this way it will be possible to clarify which is the TPMS with appropriate characteristics to construct scaffolds of ceramic materials for bone repair. A dependence of the mechanical properties with the geometry was found being the Primitive Surface which shows the highest mechanical properties.

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“…Besides the degree of degradation of the implanted biomaterial, porosity is also extremely important since bone cell growth should occur through the pores of the implanted material, promoting osseointegration 34 Porous scaffold facilitates cell migration, proliferation and differentiation, allowing the transportation of nutrients and oxygen within the structure 35 . Another relevant factor is the interconnectivity between pores to permit the invasion of osteoblasts and cell attachment.…”

Section: Macroscopic and Radiological Analysismentioning

confidence: 99%

In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes

et al. 2017

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Biomaterials with the hydroxyapatite and biopolymers such as chitosan derived of crustaceans are is an alternative for bone repair. Carbon nanotubes have been a focus of interest because they can ameliorate the biomechanical properties of biomaterials. The objective of this study was to evaluate these materials in the repair of cranial defects in rats. The animals were divided in groups: without implant (G1), implanted with the chitosan/carbon nanotube membrane (G2), and chitosan/nanotube membrane mineralized with hydroxyapatite (G3). The animals were sacrificed 5 weeks after surgery and the skulls were removed for analysis of the defect area. The results showed absence of chronic inflammatory and little bone neoformation in the defect area of all groups. In G2 and G3 there was lack of reabsorption of the biomaterial that were encapsulated by connective tissue. In conclusion, the biomaterials were biocompatible, but their specific physicochemical properties did not indicate a considerable osteoregenerative capacity.

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Design, Materials, and Mechanobiology of Biodegradable Scaffolds for Bone Tissue Engineering

Cited by 325 publications

References 221 publications

Effect of polyurethane (PU) – bioactive glass (BG) ratio on the development of BG reinforced PU scaffold

Effect of polyurethane (PU) – bioactive glass (BG) ratio on the development of BG reinforced PU scaffold

Mechanical properties of ceramic structures based on Triply Periodic Minimal Surface (TPMS) processed by 3D printing

In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes

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