Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging

González-Mancebo, Daniel; Becerro, Ana Isabel; Corral, Ariadna; García-Embid, Sonia; Balcerzyk, Marcin; García-Martín, María Luisa; Fuente, Jesús M. de la; Ocaña, Manuel

doi:10.1016/j.jcis.2020.03.101

Cited by 8 publications

(5 citation statements)

References 41 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lanthanide nanoparticles can be exploited as contrast agents for X-ray computed tomography (CT), a traditional medical imaging tool that utilizes the differential X-ray attenuation coefficients of tissues to acquire excellent 3D reconstructed images of the body and locate tumors. [57] Lanthanide nanoparticles can also absorb X-ray irradiation and convert it into UV-vis luminescence for bioimaging applications based on the photoelectric effect, called X-ray excited optical luminescence (XEOL). [58] Thus, both CT and XEOL enrich the multifunctionality of lanthanide nanoprobes and widen their applications in multimodal biological imaging.…”

Section: Lanthanide Nanoparticles Applied In X-ray Excited Bioimagingmentioning

confidence: 99%

Progress in Light‐Responsive Lanthanide Nanoparticles toward Deep Tumor Theranostics

Yan

Yang

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

Recently, lanthanide nanoparticles have aroused widespread interest in cancer theranostics by virtue of their excellent photoresponsive performance in deep-seated tumors. The abundant ladder-like energy levels, controllable emission profiles, and unique photoluminescence properties make lanthanide nanoparticles highly efficient for deep skin-penetration of near-infrared (NIR) light, concentrating light energy in tumors with negligible scattering and minimal autofluorescence from biological tissues. High-Z radio-sensitization of lanthanide elements endows lanthanide nanoparticles with a high X-ray attenuation coefficient, making them effective nanoprobes for X-ray-excited bioimaging and synchronous radiotherapy-related treatments. In this review, comprehensive progressions including the synthesis, structural characteristics of lanthanide nanoparticles, and distinct optical excitation mechanisms with NIR and X-ray triggers, are summarized. Advances in NIR-excited and X-ray-triggered cancer imaging methods and therapies are described in detail, wherein NIR-induced luminescence from upconversion nanoparticles and downconversion nanoparticles are introduced separately based on some typical sensitization. Finally, the challenges and opportunities of lanthanide nanoparticles as light-triggered cancer theranostic candidates are discussed, whose translation from bench to bedside still has a long journey to go.

show abstract

Section: Lanthanide Nanoparticles Applied In X-ray Excited Bioimagingmentioning

confidence: 99%

Progress in Light‐Responsive Lanthanide Nanoparticles toward Deep Tumor Theranostics

Yan

Yang

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…Interpretation of its luminescence spectra could provide information on the point group symmetry. Eu-doped NPs are promising luminescent probes for biomedical applications in vitro; , however, since Eu luminescence is activated by ultraviolet (UV) light, this imposes restrictions on its in vivo usage. In contrast, stimulation of upconversion luminescence (UCL) requires near-infrared (NIR) photons that fall within the “optical transparency window” of biological tissues .…”

Section: Introductionmentioning

confidence: 99%

Stokes and Anti-Stokes Luminescent Rare-Earth-Doped Tantalum Oxide Nanoparticles

et al. 2023

View full text Add to dashboard Cite

Doping of nano- and microparticles of oxides with rare earth elements (REEs) is used to fine-tune their structural, optical, and electrochemical properties. On the way to establish the structure–property relationship, we dope tantalum oxide (Ta2O5) particles with REEs to study their effect on the oxide structure and luminescence. Ta2O5 is highly perspective in medicine, catalysis, and optics, but its crystal structure is insufficiently studied. Two synthesis approaches (sol–gel and solvothermal) were used to obtain powders with different textures. Experimental and theoretical studies of amorphous and crystallized tantalum oxide NPs by means of X-ray powder diffraction, Rietveld analysis, EXAFS/XANES spectroscopy, and density functional theory calculations were performed. All samples (doped and undoped) crystallized in orthorhombic phase with no admixtures. It was demonstrated that Ta2O5 is a promising wide-spectrum luminescent material: by combining REEs, both Stokes and anti-Stokes luminescence in the visible region were obtained. By means of optical absorption spectroscopy, it was shown that the prepared samples could be classified as wide band gap semiconductors.

show abstract

“…Indeed, the major challenge to develop applications based on UC nanotechnology is related to efficiency and brightness. , Several strategies to overcome above-mentioned issues have been designed, which include surface passivation through core–shell architectures, engineering the distribution of dopants or choosing the right host for the nanophosphor. ,, Most efficient UC nanophosphors consist of fluoride-based hosts, which feature very low phonon energies that decrease the probability of nonradiative paths through multiphonon relaxation. Specifically, sodium yttrium fluoride (NaYF 4 ) stands out as the most efficient host developed to date, despite featuring low thermal stability, ,, which limits its applicability.…”

Section: Introductionmentioning

confidence: 99%

Highly Versatile Upconverting Oxyfluoride-Based Nanophosphor Films

Ngo

Cabello‐Olmo

Arroyo

et al. 2021

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Fluoride-based compounds doped with rare-earth cations are the preferred choice of materials to achieve efficient upconversion, of interest for a plethora of applications ranging from bioimaging to energy harvesting. Herein, we demonstrate a simple route to fabricate bright upconverting films that are transparent, self-standing, flexible, and emit different colors. Starting from the solvothermal synthesis of uniform and colloidally stable yttrium fluoride nanoparticles doped with Yb 3+ and Er 3+ , Ho 3+ , or Tm 3+ , we find the experimental conditions to process the nanophosphors as optical quality films of controlled thickness between few hundreds of nanometers and several micrometers. A thorough analysis of both structural and photophysical properties of films annealed at different temperatures reveals a tradeoff between the oxidation of the matrix, which transitions through an oxyfluoride crystal phase, and the efficiency of the upconversion photoluminescence process. It represents a significant step forward in the understanding of the fundamental properties of upconverting materials and can be leveraged for the optimization of upconversion systems in general. We prove bright multicolor upconversion photoluminescence in oxyfluoride-based phosphor transparent films upon excitation with a 980 nm laser for both rigid and flexible versions of the layers, being possible to use the latter to coat surfaces of arbitrary shape. Our results pave the way toward the development of upconverting coatings that can be conveniently integrated in applications that demand a large degree of versatility.

show abstract

Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging

Cited by 8 publications

References 41 publications

Progress in Light‐Responsive Lanthanide Nanoparticles toward Deep Tumor Theranostics

Progress in Light‐Responsive Lanthanide Nanoparticles toward Deep Tumor Theranostics

Stokes and Anti-Stokes Luminescent Rare-Earth-Doped Tantalum Oxide Nanoparticles

Highly Versatile Upconverting Oxyfluoride-Based Nanophosphor Films

Contact Info

Product

Resources

About