Design of a new electrogenerated polyquinone film substituted with glutathione. Towards direct electrochemical biosensors

Reisberg, S.; Acevedo, Diego F.; Korovitch, Alexandre; Piro, Benoı̂t; Noël, Vincent; Buchet, I.; Tran, Lam Dai; Barbero, César Alberto; Pham, Minh

doi:10.1016/j.talanta.2009.09.025

Cited by 20 publications

(14 citation statements)

References 19 publications

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“…Figure 2(a) is one such example of MIP protein sensors. Conducting polymers (CPs), a group of polymers exhibiting good electrical conductivity (10 −11 to 10 3 S/cm with a carrier concentration ranging between 10 12 and 10 19 /cm 3 ), have been used to increase the detection sensitivity of protein detection systems such as FETs [11,81,90,91]. Figure 2(b) displays typical examples of CPs.…”

Section: Polymers Currently Used In Analytical Detection Of Proteinsmentioning

confidence: 99%

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Functional Polymers in Protein Detection Platforms: Optical, Electrochemical, Electrical, Mass-Sensitive, and Magnetic Biosensors

Hahm

2011

Sensors

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The rapidly growing field of proteomics and related applied sectors in the life sciences demands convenient methodologies for detecting and measuring the levels of specific proteins as well as for screening and analyzing for interacting protein systems. Materials utilized for such protein detection and measurement platforms should meet particular specifications which include ease-of-mass manufacture, biological stability, chemical functionality, cost effectiveness, and portability. Polymers can satisfy many of these requirements and are often considered as choice materials in various biological detection platforms. Therefore, tremendous research efforts have been made for developing new polymers both in macroscopic and nanoscopic length scales as well as applying existing polymeric materials for protein measurements. In this review article, both conventional and alternative techniques for protein detection are overviewed while focusing on the use of various polymeric materials in different protein sensing technologies. Among many available detection mechanisms, most common approaches such as optical, electrochemical, electrical, mass-sensitive, and magnetic methods are comprehensively discussed in this article. Desired properties of polymers exploited for each type of protein detection approach are summarized. Current challenges associated with the application of polymeric materials are examined in each protein detection category. Difficulties facing both quantitative and qualitative protein measurements are also identified. The latest efforts on the development and evaluation of nanoscale polymeric systems for improved protein detection are also discussed from the standpoint of quantitative and qualitative measurements. Finally, future research directions towards further advancements in the field are considered.

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Section: Polymers Currently Used In Analytical Detection Of Proteinsmentioning

confidence: 99%

“…Conducting polymers have demonstrated their utility as a biosensor material in these applications, although their current utility is limited due to difficulties in device integration and manufacturing using traditional microfabrication processes [11,81,90,91]. …”

Section: Polymers Currently Used In Analytical Detection Of Proteinsmentioning

confidence: 99%

Functional Polymers in Protein Detection Platforms: Optical, Electrochemical, Electrical, Mass-Sensitive, and Magnetic Biosensors

Hahm

2011

Sensors

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“…The time of modification was 24 h. The GSH molecule has four possibilities for acid dissociation [16]. This tripeptide is characterized by pKa values: 2.1 (glu-COOH), 3.5 (gly-COOH), 8.7 (SH) and 9.6 (NH 2 ) [17]. In the pH range 3-8, -SH group is not dissociated and the molecule bears a net charge À1 or À2, corresponding to the dissociated carboxyl groups and ionized NH 2 group [18].…”

Section: Electrode Modificationmentioning

confidence: 99%

Drug–GSH interaction on GSH–Au modified electrodes: A cyclic voltammetry and electrochemical impedance spectroscopy study

Latus

Enache

Volanschi

2011

Journal of Electroanalytical Chemistry

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“…Nanostructured CPs as promising materials can be applied in DNA sensors due to its unique functional groups and excellent electron change ability . Compared with metal sensing platform, the major advantage associated with CPs is that they can act as a direct electronic transducer based on self‐signals without any outside indicator . With respect to analysis of DNA sequences, direct and label‐free DNA electrochemical detection seems to be in a dominant position, owing to low cost, simplicity, avoiding contamination to samples and no needing outer indicator or complicated label .…”

Section: Introductionmentioning

confidence: 99%

Sulfonated polyaniline‐graphene oxide hybrids: Synthesis and effect of monomer composition on the electrochemical signal for direct DNA detection

Lian

Chen

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

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A variety of sulfonated polyaniline-graphene oxide (SPAN-GNO) nanocomposites based on GNO, aniline (ANI) and m-aminobenzenesulfonic acid (ABSA) are prepared via changing the mole ratio of ANI to ABSA for the comparison of DNA sensing behavior. Self-signals of SPAN-GNO are employed for estimating the effect of preparation conditions [component, monomer composition (mole ratio of ANI to ABSA), and reaction time] on DNA immobilization and hybridization detection. Then, we find herein that the mole ratio of ANI to ABSA plays a lead role over other factors on hybridiza-tion efficiency. Meanwhile, the parallel experiments using methylene blue as the classic indicator verifies this conclusion. The results show that, by comparison with other mole ratio SPAN-GNO nanocomposites-modified electrodes, the mole ratio (2:3) exhibits the widest dynamic detection range from 1.0 3 10 214 to 1.0 3 10 26 M, as well as the lowest detection limit (3.06 3 10 215 M).

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Design of a new electrogenerated polyquinone film substituted with glutathione. Towards direct electrochemical biosensors

Cited by 20 publications

References 19 publications

Functional Polymers in Protein Detection Platforms: Optical, Electrochemical, Electrical, Mass-Sensitive, and Magnetic Biosensors

Functional Polymers in Protein Detection Platforms: Optical, Electrochemical, Electrical, Mass-Sensitive, and Magnetic Biosensors

Drug–GSH interaction on GSH–Au modified electrodes: A cyclic voltammetry and electrochemical impedance spectroscopy study

Sulfonated polyaniline‐graphene oxide hybrids: Synthesis and effect of monomer composition on the electrochemical signal for direct DNA detection

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