Design of a novel crosslinked HEC-PAA porous hydrogel composite for dissolution rate and solubility enhancement of efavirenz

Mabrouk, Mostafa; Chejara, Dharmesh R.; Mulla, Jameel Ahmed S.; Badhe, Ravindra V.; Choonara, Yahya E.; Kumar, Pradeep; Toit, Lisa C. du; Pillay, Viness

doi:10.1016/j.ijpharm.2015.05.082

Cited by 30 publications

(17 citation statements)

References 29 publications

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“…Today, nanomaterials play one of the most important roles in the research and development of modern pharmaceutics [1,2,3]. New material processing procedures [4,5,6,7,8], combined with different kinds of raw materials [9,10,11,12,13] and novel innovative strategies for constructing functional products [14,15,16,17,18], are frequently introduced into this application field for providing efficacious drug delivery and enhancing the therapeutic effects of active pharmaceutical ingredients (APIs). Among them, electrohydrodynamic atomization (EHDA) is a popular technique for creating nanoproducts, which mainly includes electrospraying and electrospinning.…”

Section: Introductionmentioning

confidence: 99%

The Process–Property–Performance Relationship of Medicated Nanoparticles Prepared by Modified Coaxial Electrospraying

Huang

Hou

et al. 2019

Pharmaceutics

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In pharmaceutical nanotechnology, the intentional manipulation of working processes to fabricate nanoproducts with suitable properties for achieving the desired functional performances is highly sought after. The following paper aims to detail how a modified coaxial electrospraying has been developed to create ibuprofen-loaded hydroxypropyl methylcellulose nanoparticles for improving the drug dissolution rate. During the working processes, a key parameter, i.e., the spreading angle of atomization region (θ, °), could provide a linkage among the working process, the property of generated nanoparticles and their functional performance. Compared with the applied voltage (V, kV; D = 2713 − 82V with RθV2 = 0.9623), θ could provide a better correlation with the diameter of resultant nanoparticles (D, nm; D = 1096 − 5θ with RDθ2 = 0.9905), suggesting a usefulness of accurately predicting the nanoparticle diameter. The drug released from the electrosprayed nanoparticles involved both erosion and diffusion mechanisms. A univariate quadratic equation between the time of releasing 95% of the loaded drug (t, min) and D (t = 38.7 + 0.097D − 4.838 × 105D2 with a R2 value of 0.9976) suggests that the nanoparticle diameter has a profound influence on the drug release performance. The clear process-property-performance relationship should be useful for optimizing the electrospraying process, and in turn for achieving the desired medicated nanoparticles.

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Section: Introductionmentioning

confidence: 99%

The Process–Property–Performance Relationship of Medicated Nanoparticles Prepared by Modified Coaxial Electrospraying

Huang

Hou

et al. 2019

Pharmaceutics

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“…HEC is a non-ionic polysaccharide polymer with β (1→ 4) glycosidic linkage held together with H-bonds. It is inexpensive and broadly utilized as a part of different pharmaceutical structures, wound dressing and wound remodeling system [22,23]. Previous studies have combined alginate and HEC in order to maximize their usage in different fields.…”

Section: -Introductionmentioning

confidence: 99%

Novel polysaccharide hybrid scaffold loaded with hydroxyapatite: Fabrication, bioactivity, and in vivo study

Tohamy

Soliman

Mabrouk

et al. 2018

Materials Science and Engineering: C

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The main goal of this study was to produce a novel porous scaffold for rapid in vivo bone healing behavior. Lyophilization technique was used to produce this highly porous hybrid scaffold from Na-alginate (S) and hydroxyethylcellulose (HEC) impregnated with different concentration of hydroxyapatite (HA). After cross-linking the scaffolds, their incubation was carried out in simulated body fluid (SBF) for 4 weeks at 37°C to investigate their bioactivity. A number of techniques were employed (e.g., XRD, FTIR, SEM, EDX, and texture analyzer) to characterize the designed scaffolds. It was observed that the mechanical properties of the scaffolds increase deformation energy (182±16 J/m 3 ) and rigidity gradient (19.44±0.85 Pa) after loading with HA. Furthermore, the scaffolds were implanted in femur critical size defects (2mm) of adult male Wistar rats for 6weeks. In vitro and in vivo analyses demonstrated impressive bioactivity and biocompatibility for the prepared scaffolds, especially those containing HA.Based on the obtained results we conclude that the designed scaffolds are promising solutions for bone regeneration applications.

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“…Although such hydrogel composites are promising, current approaches compromise API loading for faster release rates . Further, some systems have no control over one or more of these important aspects, including crystal size and drug release rate …”

Section: Introductionmentioning

confidence: 99%

Core–Shell Composite Hydrogels for Controlled Nanocrystal Formation and Release of Hydrophobic Active Pharmaceutical Ingredients

Badruddoza

Godfrin

Myerson

et al. 2016

Adv Healthcare Materials

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Although roughly 40% of pharmaceuticals being developed are poorly water soluble, this class of drugs lacks a formulation strategy capable of producing high loads, fast dissolution kinetics, and low energy input. In this work, a novel bottom-up approach is developed for producing and formulating nanocrystals of poorly water-soluble active pharmaceutical ingredients (APIs) using core-shell composite hydrogel beads. Organic phase nanoemulsion droplets stabilized by polyvinyl alcohol (PVA) and containing a model hydrophobic API (fenofibrate) are embedded in the alginate hydrogel matrix and subsequently act as crystallization reactors. Controlled evaporation of this composite material produces core-shell structured alginate-PVA hydrogels with drug nanocrystals (500-650 nm) embedded within the core. Adjustable loading of API nanocrystals up to 83% by weight is achieved with dissolution (of 80% of the drug) occurring in as little as 30 min. A quantitative model is also developed and experimentally validated that the drug release patterns of the fenofibrate nanocrystals can be modulated by controlling the thickness of the PVA shell and drug loading. Thus, these composite materials offer a "designer" drug delivery system. Overall, our approach enables a novel means of simultaneous controlled crystallization and formulation of hydrophobic drugs that circumvents energy intensive top-down processes in traditional manufacturing.

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Design of a novel crosslinked HEC-PAA porous hydrogel composite for dissolution rate and solubility enhancement of efavirenz

Cited by 30 publications

References 29 publications

The Process–Property–Performance Relationship of Medicated Nanoparticles Prepared by Modified Coaxial Electrospraying

The Process–Property–Performance Relationship of Medicated Nanoparticles Prepared by Modified Coaxial Electrospraying

Novel polysaccharide hybrid scaffold loaded with hydroxyapatite: Fabrication, bioactivity, and in vivo study

Core–Shell Composite Hydrogels for Controlled Nanocrystal Formation and Release of Hydrophobic Active Pharmaceutical Ingredients

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