Design of a ratiometric near-infrared fluorescent probe with double excitation for hydrazine detection in vitro and in vivo

Robust ERα-Targeted Near-Infrared Fluorescence Probe for Selective Hydrazine Imaging in Breast Cancer

“…According to previous reports, − the malononitrile group had a strong electron-withdrawing ability, which could easily be attacked by electron-rich N 2 H 4 to generate a hydrazone group (Scheme ). This change weakened the ICT process and produced obvious fluorescence “turn-off.”…”

Multi-scene visual hydrazine hydrate detection based on a dibenzothiazole derivative

“…Therefore, for benign industrial development, it is imperative to develop a reliable method to detect trace N 2 H 4 and avoid its side effects. [11][12][13][14][15] So far, many methods for hydrazine detection have been reported, such as high performance liquid chromatography (HPLC), 16 electrochemical method 17 and surface enhanced Raman spectroscopy. 18 However, these methods face many defects, including inconvenient operation and expensive instruments, so they cannot be widely used.…”

“…Therefore, for benign industrial development, it is imperative to develop a reliable method to detect trace N 2 H 4 and avoid its side effects. 11–15…”

An ESIPT-based ratiometric fluorescent probe for detecting H2O2 in water environment and biosystems

“…To date, various methods have been reported for detecting H 2 O 2 in vitro or in vivo, such as spectrophotometry, chemiluminescence, electrochemical analysis, etc. Compared with these methods, fluorescent probes have attracted much attention due to their real-time imaging, visualization, and high sensitivity and selectivity ( Li et al, 2022a ; Li et al, 2022c ; Wang et al, 2022 ; Yin et al, 2021 ; Zeng et al, 2023 ; Zhang et al, 2022 ; Zhao et al, 2022 ). Various small molecule fluorescent probes have been designed for in vitro and in vivo detection of H 2 O 2 , including benzyl, boric acid ester, arylsulfonyl ester, etc.…”