Design of a ¹³C Magnetic Resonance Probe Using a Deuterated Methoxy Group as a Long‐Lived Hyperpolarization Unit

Abstract

Das Geheimnis eines langen Lebens: Die vollständig deuterierte 13C‐markierte Methoxygruppe (13CD3O) wird als neue funktionelle Gruppe mit langlebiger Hyperpolarisierung für die Entwicklung einer empfindlichen 13C‐Kernresonanzsonde beschrieben. Die entsprechende Methode wurde für den Nachweis von hypochloriger Säure genutzt.

Observation of Glycolytic Metabolites in Tumor Cell Lysate by Using Hyperpolarization of Deuterated Glucose

“…Cells ( 1×10 7 ) were collected in a 15 mL polystyrene tube by centrifugation at 800×g and 4°C for 10 min, suspended in 10 mL of phosphate buffered saline (PBS) buffer, and supersonicated for 1 min. 36) After centrifugation at 800×g for 5 min and 4°C, the insoluble materials were removed, and protease inhibitors were added to the supernatant, which was then frozen and stored at −20°C.…”

Design of a 15N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State

“…To address this crucial issue, attention has focused on the development of molecular units that can retain the hyperpolarized state for longer periods101112131415161718. The hyperpolarization lifetime is directly correlated with the spin–lattice relaxation time ( T 1 ) of nuclei.…”

A platform for designing hyperpolarized magnetic resonance chemical probes

“…In practice, hyperpolarized [ 13 C]bicarbonate9, [ 13 C]benzoylformic acid10, [ 13 C, D 6 ] p -anisidine11 and [ 13 C]dehydroascorbate1213 have been designed as sensitive MR probes for sensing pH, H 2 O 2 , HOCl and redox status, respectively. A universal strategy—in other words, the presence of a platform structure for designing hyperpolarized MR probes—can make it easier to develop a variety of hyperpolarized MR sensors.…”