This work presented a comparison between two Voltage Controlled Oscillators (VCOs) designed in 65 nm CMOS technology. The first architecture based on a Ring Oscillator (RO) was designed using three Current Mode Logic (CML) stages connected in a loop, while the second one was based on an LC-tank resonator. This analysis aimed to choose a VCO architecture able to be integrated into a rad-hard Phase Locked Loop. It had to meet the requirements of the SpaceFibre protocol, which supports frequencies up to 6.25 GHz, for space applications. The full custom schematic and layout designs are shown, and Single Event Effect simulations results, performed with a double exponential current pulses generator, are presented in detail for both VCOs. Although the RO-VCO performances in terms of technology scaling and high-integration density were attractive, the simulations on the process variations demonstrated its inability to generate the target frequency in harsh operating conditions. Instead, the LC-VCO highlighted a lower influence through Process-Voltage-Temperature simulations on the oscillation frequency. Both architectures were biased with a supply voltage of 1.2 V. The achieved results for the second architecture analyzed were attractive to address the requirements of the new SpaceFibre aerospace standard.