Design of batch chromatography for separation of binary mixtures under reduced purity requirements

Unified design of chromatographic separation processes

“…First, the single-column shortcut method provides systematically a slightly too optimistic estimation for m FF and thus for m 3 as reported in (Siitonen et al, 2013;Kaspereit and Sainio, 2011). Consequently, the purity of the first eluting component is lower than the target.…”

“…In restrictive case, the process is operated such that the chromatograms do not overlap, and the constraints for m 1 and m 4 parameters derived in Section 4 are satisfied. Based on this assumption, a design method has been developed to calculate the cut times that lead to arbitrary target purities both for batch (Siitonen et al, 2013) and SSR (Sainio and Kaspereit 2009;Kaspereit and Sainio 2011) process in the case of Langmuir isotherm. The dimensionless m-parameters can be calculated from the cut times by using Eqs.…”

“…In addition, shortcut design approaches developed originally for one process configuration can be exploited for the design of other process schemes as well. For example, the volume of feed pulse and the cut times that lead to desired separation in batch chromatography can be estimated with a simple, recently developed shortcut method (Siitonen et al, 2013). The predicted dimensional operating parameters can be converted to dimensionless m-values (Eqs.…”

“…The feasible m-parameters corresponding to given purity constraints were first estimated by employing a shortcut design approach of fixed bed units that is based on a simple procedure applied to a single conventional chromatogram (Siitonen et al, 2013;Kaspereit and Sainio, 2011). The dimensional operating parameters of SMB scheme were then calculated by using Eqs.…”

“…They provided also analytical equations to calculate the optimal operating parameters that correspond to arbitrary purity constraints when generation of waste fraction is allowed. Recently, Siitonen et al (2013) have extended the method for operation without generation of waste stream. In addition, the analytical solution of the ideal model has been used to analyse the batch chromatography under practically relevant non-ideal conditions by combining it with a simple model of band broadening (e.g.…”