Design of Chitosan Nanocapsules with Compritol 888 ATO® for Imiquimod Transdermal Administration. Evaluation of Their Skin Absorption by Raman Microscopy

Álvarez-Figueroa, María Javiera; Narváez-Araya, Daniela; Armijo, Nicolás; Carrasco-Flores, E.A.; González-Aramúndiz, José Vicente

doi:10.1007/s11095-020-02925-6

Cited by 24 publications

(11 citation statements)

References 60 publications

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“…52,54,106,107,108,109 Rodent skin 110 is rarely due to its inherent differences to human skin. Caffeine, 52,106,109,111,112,113 lidocaine, 104 procaine, 107,114 tetracaine, 115 salicylic acid, 113 ibuprofen, 103 flufenamic acid, 105 imiquimod, 116 trans-retinol, 117,118 resorcinol, 75 niacinamide, 119 sulfathiazole sodium, 54 triamcinolone acetonide 120 and oxaprozin are among the most investigated permeants in the CRS penetration studies. 99 Next to these drugs, the penetration of enhancers such as DMSO, 54,121 propylene glycol, 103,106,107,118 polyoxyethylene-23-lauryl ether 107 and other ethoxylated emulsifier systems 114,122 has been evaluated.…”

Section: Skin Penetration Studiesmentioning

confidence: 99%

Novel aspects of Raman spectroscopy in skin research

Lunter

Klang

Kocsis

et al. 2022

Experimental Dermatology

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The analytical technology of Raman spectroscopy has an almost 100‐year history. During this period, many modifications and developments happened in the method like discovery of laser, improvements in optical elements and sensitivity of spectrometer and also more advanced light detection systems. Many types of the innovative techniques appeared (e.g. Transmittance Raman spectroscopy, Coherent Raman Scattering microscopy, Surface‐Enhanced Raman scattering and Confocal Raman spectroscopy/microscopy). This review article gives a short description about these different Raman techniques and their possible applications. Then, a short statistical part is coming about the appearance of Raman spectroscopy in the scientific literature from the beginnings to these days. The third part of the paper shows the main application options of the technique (especially confocal Raman spectroscopy) in skin research, including skin composition analysis, drug penetration monitoring and analysis, diagnostic utilizations in dermatology and cosmeto‐scientific applications. At the end, the possible role of artificial intelligence in Raman data analysis and the regulatory aspect of these techniques in dermatology are briefly summarized. For the future of Raman Spectroscopy, increasing clinical relevance and in vivo applications can be predicted with spreading of non‐destructive methods and appearance with the most advanced instruments with rapid analysis time.

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Section: Skin Penetration Studiesmentioning

confidence: 99%

Novel aspects of Raman spectroscopy in skin research

Lunter

Klang

Kocsis

et al. 2022

Experimental Dermatology

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“…Over recent years, Raman spectroscopy technology has continued to be developed, and researchers have combined Raman spectroscopy technology with a variety of other technologies to make detection technologies more effective, such as confocal Raman microscopy [ 96 ], Raman imaging technology [ 97 , 98 ], resonance Raman technology [ 99 ], surface-enhanced Raman spectroscopy (SERS) technology [ 100 ], and so forth. Raman spectroscopy technology is widely used in the fields of medicine [ 101 ], pharmaceuticals [ 102 , 103 , 104 ], cosmetics [ 105 , 106 ], carbon materials [ 107 , 108 ], geology [ 109 , 110 ], and life sciences because of its ability to rapidly analyze chemical structures in a nondestructive manner and its powerful imaging functions. Compared with other spectroscopic techniques, Raman spectroscopy has improved analytical performance for samples in aqueous solutions, biological tissues, and cells because the Raman signal of water is very weak.…”

Section: Raman Spectroscopymentioning

confidence: 99%

Vibrational Spectroscopy in Assessment of Early Osteoarthritis—A Narrative Review

Chen

Zhao

et al. 2021

IJMS

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Osteoarthritis (OA) is a degenerative disease, and there is currently no effective medicine to cure it. Early prevention and treatment can effectively reduce the pain of OA patients and save costs. Therefore, it is necessary to diagnose OA at an early stage. There are various diagnostic methods for OA, but the methods applied to early diagnosis are limited. Ordinary optical diagnosis is confined to the surface, while laboratory tests, such as rheumatoid factor inspection and physical arthritis checks, are too trivial or time-consuming. Evidently, there is an urgent need to develop a rapid nondestructive detection method for the early diagnosis of OA. Vibrational spectroscopy is a rapid and nondestructive technique that has attracted much attention. In this review, near-infrared (NIR), infrared, (IR) and Raman spectroscopy were introduced to show their potential in early OA diagnosis. The basic principles were discussed first, and then the research progress to date was discussed, as well as its limitations and the direction of development. Finally, all methods were compared, and vibrational spectroscopy was demonstrated that it could be used as a promising tool for early OA diagnosis. This review provides theoretical support for the application and development of vibrational spectroscopy technology in OA diagnosis, providing a new strategy for the nondestructive and rapid diagnosis of arthritis and promoting the development and clinical application of a component-based molecular spectrum detection technology.

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“…However, today it is known that it is not enough to have a small particle size and adequate lipophilicity; it is also necessary to have excipients that will allow the stratum corneum to be reversibly and non-aggressively opened and thus will enable the passage of nanosystems. Among the components that can be highlighted recently, the use of Compritol 888 ATO has been described as a promoter of transdermal penetration in polymeric nanoparticles that encapsulate ovalbumin and as adjuvant Imiquimod [7].…”

Section: Novel Approaches To Design Nanoparticles For Needle-free Transdermal Delivery Based On Their Compositionmentioning

confidence: 99%

“…The transdermal route of administration provides multiple advantages for achieving this goal because it reduces both the first-pass metabolism and adverse effects, is nontraumatic, and allows self-administration by the patient making it an attractive delivery route for needle-free immunization [7,8]. However, the protective barrier function of the skin can restrain the step of macromolecule and antigen absorption.…”

Section: Introductionmentioning

confidence: 99%

“…The skin is an easily accessible and highly immunocompetent organ [7,11], which can have up to 20 billion cells of various subtypes, such as keratinocytes, Langerhans cells, dendritic cells, T cells, and mast cells that contribute to the immunocompetence of skin [12]. To overcome the barrier that the stratum corneum imposes and favor transdermal permeability, various technologies have been developed, including iontophoresis [13], sonophoresis [14], magnetophoresis [15], electroporation [16], and laser microporation [17].…”

Section: Introductionmentioning

confidence: 99%

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The Importance of Nanocarrier Design and Composition for an Efficient Nanoparticle-Mediated Transdermal Vaccination

et al. 2021

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The World Health Organization estimates that the pandemic caused by the SARS-CoV-2 virus claimed more than 3 million lives in 2020 alone. This situation has highlighted the importance of vaccination programs and the urgency of working on new technologies that allow an efficient, safe, and effective immunization. From this perspective, nanomedicine has provided novel tools for the design of the new generation of vaccines. Among the challenges of the new vaccine generations is the search for alternative routes of antigen delivery due to costs, risks, need for trained personnel, and low acceptance in the population associated with the parenteral route. Along these lines, transdermal immunization has been raised as a promising alternative for antigen delivery and vaccination based on a large absorption surface and an abundance of immune system cells. These features contribute to a high barrier capacity and high immunological efficiency for transdermal immunization. However, the stratum corneum barrier constitutes a significant challenge for generating new pharmaceutical forms for transdermal antigen delivery. This review addresses the biological bases for transdermal immunomodulation and the technological advances in the field of nanomedicine, from the passage of antigens facilitated by devices to cross the stratum corneum, to the design of nanosystems, with an emphasis on the importance of design and composition towards the new generation of needle-free nanometric transdermal systems.

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Design of Chitosan Nanocapsules with Compritol 888 ATO® for Imiquimod Transdermal Administration. Evaluation of Their Skin Absorption by Raman Microscopy

Cited by 24 publications

References 60 publications

Novel aspects of Raman spectroscopy in skin research

Novel aspects of Raman spectroscopy in skin research

Vibrational Spectroscopy in Assessment of Early Osteoarthritis—A Narrative Review

The Importance of Nanocarrier Design and Composition for an Efficient Nanoparticle-Mediated Transdermal Vaccination

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