Design of co-crystallization processes with regard to particle size distribution

Holaň, Jan; Ridvan, Luděk; Billot, Pascal; Štěpánek, František

doi:10.1016/j.ces.2015.01.045

Cited by 27 publications

(27 citation statements)

References 19 publications

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“…This may be explained by the fact that the cocrystals produced after the scale-up were extruded at 100 rpm, facilitating greater high shear kneading in the mixing zones, causing greater interaction between the particles producing greater kinetic energy in the extruder barrel. This will lead to a more effective deagglomeration, as the particles come into close contact at high speeds, preventing aggregates from forming during the grinding process [ 12 ].…”

Section: Resultsmentioning

confidence: 99%

“…The modified interactions will have the potential to improve the physical properties of the API such as the molecules solubility, permeability, particle size, ionization, physical and chemical stability and many more [ 7 , 8 , 9 ]. This will provide greater bioavailability, whilst the drug molecule itself is unchanged, as all modifications occur at the supramolecular level (intermolecular interactions, hydrogen bonding, molecular packing) [ 10 , 11 , 12 ]. Studies have found that the multi layered structure of cocrystals improve the mechanical properties, give better flow properties and improve compressibility, which assists the dosage form preparation [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals

et al. 2021

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The aim of the study was the manufacturing and scale-up of theophylline-nicotinamide (THL-NIC) pharmaceutical cocrystals processed by hot-melt extrusion (HME). The barrel temperature profile, feed rate and screw speed were found to be the critical processing parameters with a residence time of approximately 47 s for the scaled-up batches. Physicochemical characterization using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction of bulk and extruded materials revealed the formation of high purity cocrystals (98.6%). The quality of THL-NIC remained unchanged under accelerated stability conditions.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals

et al. 2021

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“…V chirálním prostředí mohou jednotlivé enantiomery dané sloučeniny vykazovat různé chemické nebo fyzikální vlastnosti v důsledku rozdílného prostorového uspořádání, a tím poskytovat odlišné stereoselektivní interakce 7 . Rozdílné účinky enantiomerů biologicky aktivních látek v živých organismech jsou obecně známé 8 . Velká pozornost je věnována zejména odlišnému chování enantiomerů léčiv, pesticidů, nových psychoaktivních sloučenin (NPS) a jejich metabolitů [9][10][11][12][13][14][15][16][17][18] .…”

Section: úVodunclassified

Sub/supercritical Fluid Chromatography for Chiral Compounds Analysis

Kalíková¹,

Folprechtová²,

Kadlecová³

2022

Chem. Listy

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Chirality is an essential feature of nature as it is common for many biologically active compounds. The different biological effects of individual enantiomers in a chiral environment are generally known. Therefore, there is a need for fast, efficient, and robust methods for their separation, quantification, and purification, too. The easiest way is to use chromatographic methods utilizing chiral stationary phases. Sub/supercritical fluid chromatography has become popular in the field of enantioselective separations in various scopes and, in some cases, has become a method of the first choice. Therefore, this review article covers actual trends and possibilities of sub/supercritical fluid chromatography in enantioseparations. Ways to influence enantioselectivity of the separation system by column coupling, screening approaches, and processes of methodical development for fast and efficient analyses are discussed. Sub/supercritical fluid chromatography under suitable experimental conditions provides fast and highly efficient separation of chiral compounds.

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“…Co-crystals are ordinarily produced by moderate dissipation of the arrangements of the two segments. This methodology has been effective with atoms of correlative hydrogen holding properties, in which case co-crystallization is probably going to be thermodynamically liked [23]. There are many other methods for producing co-crystals.…”

Section: Productionmentioning

confidence: 99%

A Comprehensive Mini Review on Co-Crystallization Process

Das

Amin

Sarma

et al. 2021

JPRI

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Co‑crystal chemistry has recently attracted supramolecular scientists. Co-crystals are comprising of hydrogen bonding assembly between different molecules. Many issues related to the performance characteristics of an active pharmaceutical ingredient (API) can be resolved using the co-crystallization approach. A proper understanding of the crystal structure of an API is required for the successful formation of co-crystals with the selected co‑former. Co-crystal chemistry has recently attracted scientists from the super molecules. Co crystals consist of the assembly of hydrogen bonds between various molecules. Many problems related to the performance characteristics of an active pharmaceutical ingredient (API) can be solved using the method of co-crystallization. Co-Crystals offer an alternate pathway where any API, paying little mind to be acidic, essential, or ionizable gatherings, might be co-gem. This aspect also helps to complement existing methods by reintroducing molecules with limited pharmaceutical profiles based on their non-ionizable functional groups.

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Design of co-crystallization processes with regard to particle size distribution

Cited by 27 publications

References 19 publications

Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals

Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals

Sub/supercritical Fluid Chromatography for Chiral Compounds Analysis

A Comprehensive Mini Review on Co-Crystallization Process

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