Design of dialdehyde cellulose crosslinked poly(vinyl alcohol) hydrogels for transdermal drug delivery and wound dressings

Poly(vinyl alcohol) Hydrogels: The Old and New Functional Materials

“…PVA can also react with bifunctional compounds such as aromatic diglycidyl ether to obtain crosslinked PVA with a stereoscopic network structure, which improves the chemical stability and selectivity of PVA hydrogels [30]. As shown in Figure 3(a), PVA-based hydrogels such as 4-carboxybenzaldehyde (CBA)-PVA [38] and 2,3-dialdehyde cellulose (DAC)-PVA [39] have also been reported.…”

“…With the swelling of the hydrogels due to the Donnan potential, the releasing time of drugs can be greatly prolonged while the dosage of the drug can be reduced [63,64]. Since PVA is stable to environmental stimulus, the releasing mechanism of drugs from PVA gels is proved and calculated as zero-order releasing mode [39,62,65,66]. As can be seen in Figure 4(a), PEG/PVA hydrogel system could perform stable releasing of aspirin under different pH buffer solutions [50].…”

“…Developing a nontoxic, super-absorbent, and antibacterial hydrogel as a skin wound dressing is of significant importance. As a wound dressing, PVA hydrogels can protect the wound and reduce the second injuries of external environment stimulus and external mechanical force applied to the wound, which is convenient for clinical operation (Figure 4(c)) [39]. Moreover, PVA hydrogels also have good permeability to water and oxygen and high moisture content that can maintain the moist environment of a wound during wound healing, promote the growth of new tissue, and promote wound healing [59,72].…”

A freeze–thaw PVA hydrogel loaded with guava leaf extract: physical and antibacterial properties

“…23 PVA-based hydrogel has been successfully applied as a wound dressing, a drug delivery system, and tissue engineering. [24][25][26] The use of hydrogels as wound coverings has been extensively studied since the skin, as the outer covering of the body, is the largest organ that protects internal organs and maintains normal body temperature. 27 If there is damage to the skin tissue due to an injury, the function of the skin will be impaired.…”

Transcutaneous Drug Delivery Systems Based on Collagen/Polyurethane Composites Reinforced with Cellulose

“…At the same time, cellulose derivatives have proven to be versatile materials with multiple applications in a wide range of fields. Thus, cellulose derivatives have found their use in making seedling pots [ 10 ], surgical sutures [ 11 , 12 ], patches for topical applications [ 13 , 14 , 15 ], or for the design of biofriendly materials that have proven effective for heavy-metal retention [ 16 , 17 , 18 , 19 , 20 ]. The emergence of nanostructured biomaterials has paved the way for the design of cellulose-based composites for the controlled transport of drugs or other bioactive principles [ 21 , 22 , 23 , 24 , 25 ].…”