Design of Experiments Assessment for the Determination of Moisture Content in Five Herbal Raw Materials Contained in Tea Products

Henríquez, Luis Castillo; Viales, Eleaneth Baltodano; Arguedas, Nils Antonio Ramírez; Zúñiga, Rolando Vargas; Hanley, Georgia

doi:10.33084/bjop.v3i1.1236

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…A response optimizer was performed to define the test conditions that allow obtaining a response according to a target value from a certified method (Figure 5). The designed model was able to explain the response variability for all samples based on the R 2 (adj) [61]. Furthermore, in previous research from our group, we have employed QbD for the development of different pharmaceutical formulations.…”

Section: Quality By Design Approach For Industrial Pharmacy In the Ac...mentioning

confidence: 99%

Quality by Design: A Suitable Methodology in Industrial Pharmacy for Costa Rican Universities

Henríquez¹,

Murillo-Castillo²,

Ramírez-Arguedas³

et al. 2022

Preprint

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The aim of this review is to present the Quality by Design (QbD) model as a suitable methodology to perform research in the academic Costa Rican institutions that teach Pharmacy. Pubmed, Science Direct, and Google Scholar databases were screened for original and review papers, as well as short communications published not more than 10 years ago. Publications were screened by title and abstract. Relevant references were used to develop three important themes: The University’s Research Model in Costa Rica, QbD Model, and QbD as a Research Methodology for Industrial Pharmacy in the Academy. In this sense, the QbD model is a great methodology for carrying out research projects regarding Pharmaceutical Sciences but especially for Drug Development. Academic research based on this model enables training and developing practical, scientific, and leadership skills in pharmacy students. The generated knowledge can be shared in the classrooms, which represents an ideal environment to communicate their research results and to foster collaborative work between researchers, professors, and students. The participation of all these actors allows a high level of commitment to research work, which benefits the scientific advancement of the university and society. It is important to visualize the student body as potential key actors in the research process, encouraging in them the desire to become trained scientific researchers who want to pursue a career in the academy, giving continuity to it.

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Section: Quality By Design Approach For Industrial Pharmacy In the Ac...mentioning

confidence: 99%

Quality by Design: A Suitable Methodology in Industrial Pharmacy for Costa Rican Universities

Henríquez¹,

Murillo-Castillo²,

Ramírez-Arguedas³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…For instance, Castillo et al evaluated a sample's mass and temperature impact on the moisture content in Camellia sinensis, Cassia fistula, Chamaemelum nobile, Lippia alba, and Tilia platyphyllos using a gravimetric method developed through a 3 2 full factorial design. A response optimizer was used to define the test conditions that allow results to be obtained according to a target value from a certified method (Figure 6) [105]. The designed model was able to explain the response variability for all samples based on the R 2 (adj), which led to the definition of the range of mass and temperature for the analyses based on each materials' properties, as well as considering the capacity, precision, moisture range, heating technology, and operational temperature range of the dryer and the available moisture balances.…”

Section: Quality Controlmentioning

confidence: 99%

Quality by Design: A Suitable Methodology in Industrial Pharmacy for Costa Rican Universities

et al. 2022

Self Cite

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This review aims to present the Quality by Design (QbD) model as a suitable methodology to perform research in the academic Costa Rican institutions that teach Pharmacy. Pubmed, Science Direct, and Google Scholar databases were screened for original research papers and review papers published not more than ten years ago. Institutional repositories from the different universities were reviewed as well. The QbD model stands out as a great methodology for carrying out research projects regarding Pharmaceutical Sciences, but especially for Industrial Pharmacy, where it has contributed in terms of formulation development, manufacturing, and quality control. Academic research based on this model enables the training and development of practical, scientific, and leadership skills in Industrial Pharmacy students. The generated knowledge can be shared in classrooms, which represents an ideal environment to communicate research results and to foster collaborative work between researchers, professors, and students. Moreover, research performed through a QbD approach increases the confidence shown by the industrial sector and health regulatory authorities in the quality of the research, products, and knowledge that are developed and created in an Academy. As a result, the implementation of the model has allowed the creation, transfer, and materialization of knowledge from the Costa Rican Academy to different local pharmaceutical industries.

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Pharmacognostic Study of Sangkareho Root (Callicarpa longifolia Lam.) from Pelaihari, South Kalimantan

2020

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Sangkareho (Callicarpa longifolia Lam.) is used traditionally by one of Kalimantan's indigenous tribes, the Dayak Tunjung tribe as a medicine for colds and inflammation, where the plant parts used are the roots. Considering its very potential prospects, research aimed at providing a scientific basis for plant pharmacognostic data needs to be carried out with qualitative methods. The qualitative examination is done by several methods including test identification of organoleptic, macroscopic, microscopic, and chemical compounds. Organoleptic test results showed that the roots have a light brown color, bitter and slightly spicy, and a rather pungent odor. Microscopic test results showed sangkareho root has a length of � 90 cm; width of � 1 cm; and for the form of a spear with a ride root system. Microscopic observations are found in the form of epidermal cells, exodermis, cortex, endodermis, bearing files, calcium oxalate crystals, and stone cells. The identification of chemical compounds showed positive results against alkaloids, flavonoids, saponins, and triterpenoids. The thin-layer chromatography profile shows four separate stains with eluent ethyl acetate : methanol : water in a ratio of 8 : 2 : 1, respectively.

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Design of Experiments Assessment for the Determination of Moisture Content in Five Herbal Raw Materials Contained in Tea Products

Cited by 3 publications

References 43 publications

Quality by Design: A Suitable Methodology in Industrial Pharmacy for Costa Rican Universities

Quality by Design: A Suitable Methodology in Industrial Pharmacy for Costa Rican Universities

Quality by Design: A Suitable Methodology in Industrial Pharmacy for Costa Rican Universities

Pharmacognostic Study of Sangkareho Root (Callicarpa longifolia Lam.) from Pelaihari, South Kalimantan

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