Design of experiments in medical physics: Application to the AAA beam model validation

Dufreneix, S.; Legrand, C.; Bartolo, C. Di; Bremaud, M.; Mesgouez, J.; Tiplica, Téodor; Autret, D.

doi:10.1016/j.ejmp.2017.05.068

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…The choice of an appropriate algorithm is crucial to avoid inaccuracies in the dose calculation. However, when comparing the dose calculated between different studies, the beam model used should be taken into account in order to avoid biased comparisons, since beam parameters, tumour size and location may all have a non-negligible impact on the dose calculation accuracy depending on the beam model used [24]. Guidelines to follow for the commissioning of a new TPS are provided in [25], but in order to have a standard beam model for dose calculation (i.e.…”

Section: Treatment Planning Systems and Dose Calculation Algorithmsmentioning

confidence: 99%

A review of dose calculation approaches with cone beam CT in photon and proton therapy

2020

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Background and purpose: The use of cone beam computed tomography (CBCT) for performing dose calculations in radiation therapy has been widely investigated as it could provide a quantitative analysis of the dosimetric impact of changes in patients during the treatment. The aim of this review was to classify different techniques adopted to perform CBCT dose calculation and to report their dosimetric accuracy with respect to the metrics used. Methods and materials: A literature search was carried out in PubMed and ScienceDirect databases, based upon the following keywords: "cone beam computed tomography", "CBCT", "cone beam CT", "dose calculation", "accuracy". Sixty-nine peer-reviewed relevant articles were included in this review: thirty-one patient studies, fifteen phantom studies and twenty-three patient & phantom studies. Most studies were found to have focused on head and neck, lung and prostate cancers. Results: The techniques adopted to perform CBCT dose calculation have been grouped in six categories labelled as (1) pCT calibration, (2) CBCT calibration, (3) HU override, (4) Deformable image registration, (5) Dose deformation, and (6) Combined techniques. Differences between CBCT dose and reference dose were reported both for target volumes and OARs. Conclusions: A comparison among the available techniques for CBCT dose calculations is challenging as many variables are involved. Therefore, a set of reporting standards is recommended to enable meaningful comparisons among different studies. The accuracy of the results was strongly dependent on the image quality, regardless of the methods used, highlighting the need for dose validation and quality assurance standards. the results are highly variable due to different devices, protocols, datasets, metrics of comparison, treatment sites and treatment planning systems (TPS) being reported in the different studies. This wide variety in the dose reconstruction methodologies and reporting methods used in this expanding field has identified a need to review the current status of the field. This work considers the current

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Section: Treatment Planning Systems and Dose Calculation Algorithmsmentioning

confidence: 99%

A review of dose calculation approaches with cone beam CT in photon and proton therapy

2020

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“…The paper of Dufreneix S. et al [10] introduces the reader in the use of experimental designs (a well-known branch of the statistical science) and the analysis of multiparametric problems related to the quality assurance of beam models' validation. The end point of their study was to show how these methods can help define the optimal measurement set to meet the QA acceptance criteria and how they can be used to infer the main factors affecting the investigated variable.…”

Section: Radiotherapymentioning

confidence: 99%

1st European Congress of Medical Physics September 1–4, 2016; Medical Physics innovation and vision within Europe and beyond

et al. 2017

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“…Since most of CPPs are distinctly related to multiple CQAs, intersections between different surfaces (the same CPP explored against different CQAs) generate a map that represents the product quality for each value in the potential operating range from this CPP. The analysis of these maps allows the determination of the optimal operating ranges of each CPP, enabling to improve the quality of the development process [23][24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Multiparametric quality by design-fuzzy model applied in the development of a biomedical measuring system

Velázquez

Monteiro

Louzada

et al. 2020

Int. J. Metrol. Qual. Eng.

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This work presents the adaptation of the Quality by Design (QbD) approach for application in the quality assurance of a biomedical measuring system under development. First attempts in applying QbD to biomedical technologies indicated a significantly higher number of parameters than its traditional application in the pharmaceutical industry. These preliminary studies did not fulfill the QbD stage of Design Space (DS) configuration for biomedical devices, an essential step to identifying the proper operating ranges of parameters and guaranteeing quality features. Therefore, it persisted the challenge of configuring DS for health devices, overcoming dependences in the interaction of multiple process parameters and critical attributes. The present work develops a hybrid QbD-Fuzzy approach for multiparametric DS configuration. The proposed method was applied in the development phase of a low-cost and high-sensitive magnetic measuring system for locating metallic foreign bodies in patients, employing sensors based on the Giant Magnetoimpedance effect. The results provided the acceptable operating ranges of the multiple process parameters to ensure the biomedical equipment's suitability. The proposed strategy contributes to the QbD implementation in biomedical technologies and, therefore, promotes the reliability of diagnostic and therapeutic results in the clinical environment.

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Design of experiments in medical physics: Application to the AAA beam model validation

Cited by 6 publications

References 21 publications

A review of dose calculation approaches with cone beam CT in photon and proton therapy

A review of dose calculation approaches with cone beam CT in photon and proton therapy

1st European Congress of Medical Physics September 1–4, 2016; Medical Physics innovation and vision within Europe and beyond

Multiparametric quality by design-fuzzy model applied in the development of a biomedical measuring system

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