Abstract:Posterior capsular opacification (PCO), resulting from the undemanded intracapsular cell proliferation, is the most common complication of intraocular lens (IOL) implantation after cataract surgery. In recent years, IOL has become...
“…While the AuNPs@MIL-PGE group was cultured for another 72 h, the number of cells was significantly reduced compared with 24 h and considerably less than the PGE group. This proved that the AuNPs@MIL-PGE material could effectively remove the residual HLECs on the surface while retaining the excellent ability of PGE, whose good functionality of anti-adhesion and anti-cell migration ability has been demonstrated and introduced in detail in our previous work [ 32 ]. Fig.…”
Section: Resultsmentioning
confidence: 80%
“…After introducing AuNPs@MIL into the poly (glycidyl methacrylate)-co-2-(2-ethoxyethoxy) ethyl acrylate (PGE) system, novel IOL bulk materials with synergistic therapeutic effects were prepared by radical polymerization. In our previous work [ 31 , 32 ], the reliability of PGE as a novel IOL bulk material was verified. After AuNPs@MIL was doped into the IOL bulk material PGE, the MIL structure could not only prevent the inevitable agglomeration during the preparation of AuNPs but also prevent the deactivation caused by protein adsorption.…”
Posterior capsular opacification (PCO) is the most common complication after cataract surgery. Present strategies can’t meet the clinical needs of long-term prevention. This research reports a novel intraocular lens (IOL) bulk material with high biocompatibility and synergistic therapy. Gold nanoparticles (AuNPs) doped MIL-101-NH2 metal–organic frameworks (MOFs) (AuNPs@MIL) was firstly fabricated via in situ reductions. Then the functionalized MOFs were uniformly mixed with glycidyl methacrylate (GMA) and 2-(2-ethoxyethoxy) ethyl acrylate (EA) to form the nanoparticle doped polymer (AuNPs@MIL-PGE), and which was used to fabricate IOL bulk materials. The materials’ optical and mechanical properties with different mass contents of nanoparticles are investigated. Such bulk functionalized IOL material could efficiently remove residual human lens epithelial cells (HLECs) in the capsular bag in the short term, and can prevent PCO on demand in the long run by near-infrared illumination (NIR) action. In vivo and in vitro experiments demonstrate the biosafety of the material. The AuNPs@MIL-PGE exhibits excellent photothermal effects, which could inhibit cell proliferation under NIR and doesn’t cause pathological effects on the surrounding tissues. Such functionalized IOL can not only avoid the side effects of the antiproliferative drugs but also realize the enhanced PCO prevention in clinical practice.
“…While the AuNPs@MIL-PGE group was cultured for another 72 h, the number of cells was significantly reduced compared with 24 h and considerably less than the PGE group. This proved that the AuNPs@MIL-PGE material could effectively remove the residual HLECs on the surface while retaining the excellent ability of PGE, whose good functionality of anti-adhesion and anti-cell migration ability has been demonstrated and introduced in detail in our previous work [ 32 ]. Fig.…”
Section: Resultsmentioning
confidence: 80%
“…After introducing AuNPs@MIL into the poly (glycidyl methacrylate)-co-2-(2-ethoxyethoxy) ethyl acrylate (PGE) system, novel IOL bulk materials with synergistic therapeutic effects were prepared by radical polymerization. In our previous work [ 31 , 32 ], the reliability of PGE as a novel IOL bulk material was verified. After AuNPs@MIL was doped into the IOL bulk material PGE, the MIL structure could not only prevent the inevitable agglomeration during the preparation of AuNPs but also prevent the deactivation caused by protein adsorption.…”
Posterior capsular opacification (PCO) is the most common complication after cataract surgery. Present strategies can’t meet the clinical needs of long-term prevention. This research reports a novel intraocular lens (IOL) bulk material with high biocompatibility and synergistic therapy. Gold nanoparticles (AuNPs) doped MIL-101-NH2 metal–organic frameworks (MOFs) (AuNPs@MIL) was firstly fabricated via in situ reductions. Then the functionalized MOFs were uniformly mixed with glycidyl methacrylate (GMA) and 2-(2-ethoxyethoxy) ethyl acrylate (EA) to form the nanoparticle doped polymer (AuNPs@MIL-PGE), and which was used to fabricate IOL bulk materials. The materials’ optical and mechanical properties with different mass contents of nanoparticles are investigated. Such bulk functionalized IOL material could efficiently remove residual human lens epithelial cells (HLECs) in the capsular bag in the short term, and can prevent PCO on demand in the long run by near-infrared illumination (NIR) action. In vivo and in vitro experiments demonstrate the biosafety of the material. The AuNPs@MIL-PGE exhibits excellent photothermal effects, which could inhibit cell proliferation under NIR and doesn’t cause pathological effects on the surrounding tissues. Such functionalized IOL can not only avoid the side effects of the antiproliferative drugs but also realize the enhanced PCO prevention in clinical practice.
“…To provide our readers with more comprehensive information, we have compiled a list of drugs that can be contained in contact lenses (Table ). ,,− …”
The eye contains a complex network of physiological information and biomarkers for monitoring disease and managing health, and ocular devices can be used to effectively perform point-of-care diagnosis and disease management. This comprehensive review describes the target biomarkers and various diseases, including ophthalmic diseases, metabolic diseases, and neurological diseases, based on the physiological and anatomical background of the eye. This review also includes the recent technologies utilized in eyewearable medical devices and the latest trends in wearable ophthalmic devices, specifically smart contact lenses for the purpose of disease management. After introducing other ocular devices such as the retinal prosthesis, we further discuss the current challenges and potential possibilities of smart contact lenses.
“…The first generation of IOL was made of polymethylmethacrylate [ 18 ]. Subsequently, hydrophilic or hydrophobic acrylate polymer with a higher refractive index was developed as the second generation IOL materials, which was foldable and alleviated large cornea incision during the surgery [ [19] , [20] , [21] ]. But, despite all these, the current IOLs are still too stiff to deform with ciliary muscle movements, resulting in fixed focal length and lack the ability to adjust focus for different distances [ 22 , 23 ].…”
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