Design of irreversible optical nanothermometers for thermal ablations

Gustafson, Tiffany P.; Cao, Qian; Wang, Steven T.; Berezin, Mikhail Y.

doi:10.1039/c2cc37271a

Cited by 35 publications

(40 citation statements)

References 27 publications

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“…32 bBSA is known to bind to both glass and Au surfaces; on glass, through non-covalent physisorption, while on Au surfaces, through coordinative interaction between gold and the bBSA thiol groups. [54][55][56] When AuNS substrates were coated with bBSA monolayers, their LSPR peak positions were red-shifted by about 6-9 nm, due to the higher refractive index of bBSA compared to air ( Figure S4, Supporting Information). Similarly, a previous report showed bBSA provides a spacing of ~4-8 nm between the dye molecules and the Au surface, while the streptavidin attached to the dyes, provides an additional separation distance of ~4 nm, resulting to a total spacing of ~12 nm.…”

Section: 61mentioning

confidence: 99%

“…[54][55][56] SEM imaging showed that the surfaces of substrates fabricated with S-AuNS (Figure 3a) and L-AuNS ( Figure 3d) were densely populated by particles. SAuNS were more homogeneously distributed on the surface of glass substrates compared to L-AuNS, possibly due to an increased propensity of L-AuNS to aggregate in solution before self-assembly.…”

Section: Synthesis Of Self-assembled Monolayers Of Auns Grafted On Glmentioning

confidence: 99%

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Gold Nanostar Substrates for Metal-Enhanced Fluorescence through the First and Second Near-Infrared Windows

et al. 2017

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Gold nanostars; self-assembled monolayers; near infrared; NIR-II; metal enhanced fluorescence; localized surface plasmon resonance; fluorescence lifetime.Gold nanostars (AuNS) are receiving increasing attention for their potential applications in bionanotechnology, because of their unique optical properties related to their complex branched morphology. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 2 confirming that AuNS substrates are promising NIR-MEF platforms for the development of ultrasensitive biosensing applications. Using fluorescence lifetime measurements to semi-quantitatively deconvolute the excitation enhancement from emission enhancement, as well as modelling to simulate the electric field enhancement, we show that a combination of enhanced excitation and an increased radiative decay rate, accompanied by an increase to the quantum yield, contribute to the observed large enhancement. AuNS with different morphological features exhibit significantly different excitation enhancement, indicating the important role of particle morphology on the magnitude of electromagnetic field enhancement, and the resulting enhancement factor. Importantly, enhancement factors of up to 50 times are also achieved in the NIR-II region, suggesting that this system holds promise for the future development of bright probes for NIR/NIR-II biosensing and bioimaging.

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Section: 61mentioning

confidence: 99%

Section: Synthesis Of Self-assembled Monolayers Of Auns Grafted On Glmentioning

confidence: 99%

Gold Nanostar Substrates for Metal-Enhanced Fluorescence through the First and Second Near-Infrared Windows

et al. 2017

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“…Gemcitabine interferes with DNA synthesis following phosphorylation by deoxycytidine kinase and hence is used as a first-line therapy for pancreatic cancer treatment (Gustafson et al 2013). However, rapid development of resistance limits its application.…”

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Nanoparticle-based combination drug delivery systems for synergistic cancer treatment

Choi

Thapa

Yong

et al. 2016

Journal of Pharmaceutical Investigation

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Despite being a leading cause of death worldwide, cancer remains difficult to treat due to the development of drug resistance and severe adverse effects associated with conventional chemotherapy. Hence, combination chemotherapy is theoretically advantageous owing to the synergistic effects of drugs and suppression of drug resistance.Nanoparticle-mediated chemotherapeutic delivery is a promising approach for the effective treatment of various cancers because it may simultaneously enhance therapeutic effects and reduce side effects. The loading of multiple chemotherapeutic agents to these systems could additionally improve the antineoplastic efficacy. This review highlights recent advances in combination chemotherapy using small-molecule chemotherapeutic agents via nanocarrier systems, e.g., liposomes, polymeric micelles, dendrimers, polymer-drug conjugates, and mesoporous silica nanoparticles. Specifically, it emphasizes the unique properties of these systems that make them amenable to optimized treatments with respect to efficacy and safety and clarifies areas in which current therapeutic strategies can be improved.

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“…11 Recently, we approached this problem by developing nanothermometers composed from a gold nanorod core, temperature sensitive linker, and fluorescent dye. 12 The nanothermometers demonstrated low fluorescence due to a self-quenching mechanism at temperature below 50 ºC and became highly fluorescent above 70 ºC.…”

Section: Introductionmentioning

confidence: 99%

Molecular thermometers for potential applications in thermal ablation procedures

et al. 2013

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Thermal ablation is a promising minimally invasive method for treating tumors without surgical intervention. Thermal ablation uses thermal sources such as lasers, radiowaves or focused ultrasound to increase the temperature of the tumor to levels lethal to cancer cells. This treatment based on heat therapy may be problematic as the temperature of the operation site is unknown. To address this problem, we developed optical molecular thermometers that can potentially measure the temperature on a molecular scale and be compatible with in vivo measurements. The thermometers are centered on a combination of two fluorophores emitting in two distinct spectral ranges and having different temperaturedependent emission properties. In this design, a fluorophore with relatively insensitive temperature-dependent fluorescence serves as a reference while another sensitive fluorophore serves as a sensor. We have demonstrated the feasibility of this approach using a coumarin-rhodamine conjugate. The sensitivity of the construct to the clinically relevant ablation temperatures (20-85 ºC) was demonstrated in vitro.

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Design of irreversible optical nanothermometers for thermal ablations

Abstract: Nanothermometers composed from a gold nanorod core, temperature sensitive linker and fluorescent dye are reported. The nanothermometers have low fluorescence due to a self-quenching mechanism at temperature below 50°C and become highly fluorescence above 70°C.

Cited by 35 publications

References 27 publications

Gold Nanostar Substrates for Metal-Enhanced Fluorescence through the First and Second Near-Infrared Windows

Gold Nanostar Substrates for Metal-Enhanced Fluorescence through the First and Second Near-Infrared Windows

Nanoparticle-based combination drug delivery systems for synergistic cancer treatment

Molecular thermometers for potential applications in thermal ablation procedures

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