Design of Liver Functional Reserve Estimation Technique Based on Optical Densitometry

Abstract

This work is aimed at creating a modified invasive technique for assessing the liver’s functional reserves. A study of the degree of hepatodepression is carried out by measuring the plasma elimination of indocyanine green using the method of optical densitometry. This paper presents test results for an aqueous solution and an albumin solution, as well as the results of measurements of plasma elimination of indocyanine green for patients with liver disease. Perfecting the proposed method will make an important scientific contribution to modern diagnostic medicine. Diagnosing the stages in the progression of the disease and its developing complications can make it possible to rapidly correct the patient’s treatment algorithm, achieving positive outcomes in medical practice.

Optical Diagnostics in Human Diseases

“…The dye was administered intravenously to a patient, and then it was observed how long it took the liver to eliminate it from blood plasma. The concentration of indocyanine green in the blood was measured using the developed optical setup [ 8 ].…”

Joint Methodology Based on Optical Densitometry and Dynamic Light Scattering for Liver Function Assessment

“…However, there is an upper limit to the reliable concentration measurement. Calibration curves for the Beer–Lambert–Bouguer law correction can be used to increase the method’s reliability for high concentrations [ 15 , 16 , 17 ].…”

Current management of liver diseases and the role of multidisciplinary approach

“…Non-invasive determination of absolute indocyanine green (ICG) concentration and methods to calculate circulating blood volume have not been developed. To solve this problem, Savchenko et al [ 35 ] experimented with the use of combined methods (invasive and non-invasive) to assess the rate of removal of dyes on a single platform, which allows post-processing of data obtained by optical densitometry. This study aimed to develop an invasive method to estimate plasma elimination of ICG for diagnosing liver function.…”

“…This platform is cost-effective, easy of use, and allows a quick real-time determination of results. The authors suggest that this new system can evaluate liver function and predict its recovery with higher accuracy than existing methods[ 35 ]. Schwarz et al [ 36 ] conducted an extensive retrospective analysis among patients who were diagnosed for preoperative ICG clearance before hepatic resection in a university hospital setting.…”