Cultural relics are valuable society resource for the countries. In order to protect the cultural relics effectively, a cultural relics protection system based on ZigBee and WiFi is proposed in this paper. The system is based on a wireless sensor network that collects information about the surrounding environment and of the cultural relics through sensors and detects any position changes and temperature or humidity anomalies of the monitored cultural relics. When the position of the monitored cultural relics changes or the temperature and humidity are not conducive to the storage of cultural relics, the system will send an alarm to the control center to inform the staff to handle the situation accordingly. The detailed implementation of the system is demonstrated.