Design of naltrexone-loaded hydrolyzable crosslinked nanoparticles

Yin, Wusheng; Akala, Emmanuel O.; Taylor, Robert E.

doi:10.1016/s0378-5173(02)00297-1

Cited by 39 publications

(30 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The fractions were compared by TLC (silica gel using petroleum ether-EtOAc as solvent), and those giving similar coumarin spots were combined and further purified on preparative TLC to give Farnesiferol C (5.43 mg). The melting point, H-and C-NMR data of the obtained isolated farnesifeol C were confirmed according to previously published works [21,22,23].…”

Section: Preparation Of Extract and Chromatographysupporting

confidence: 53%

Novel thermosensitive poly (N-isopropylacrylamide-co-vinylpyrrolidone-co-methacrylic acid) nanosystems for delivery of natural products.

Mashinchian¹,

Salehi²,

Dehghan³

et al. 2010

Int J Drug delivery

View full text Add to dashboard Cite

The purpose of this research was to synthesize polymer based smart nanosystems for delivery of important bioactive natural products such as sesquiterpene coumarin derivatives of ferula szowitsiana, farnesiferol C as a potent anticancer. To this aim, polymeric micelles were prepared using Nisopropylacrylamide (NIPAAM), vinyl pyrrolidone (VP) and methacrylate (MAA) as monomers which were cross-linked with N, N-methylene bisacrylamide (MBA). The molar ratio of the PNIPAAm: VP: MAA group was 75.7:9.5:14.8. These micelles were further characterized upon their physicochemical properties using particle size analyzer, FT-IR, H-/C-NMR, HPLC. Particle size analyzer resulted in ~500 nm micelles with ~95% drug entrapments. Drug release from the polymeric micelles after 300 hours at 37°C and 40°C were 60 and 98 %, respectively. Upon these findings, it is proposed that the P (N-isopropylacrylamide-co-Methacrylic acid-coVinylpyrrolidone) micelles may be considered as thermosensitive delivery nanosystem.

show abstract

Section: Preparation Of Extract and Chromatographysupporting

confidence: 53%

Novel thermosensitive poly (N-isopropylacrylamide-co-vinylpyrrolidone-co-methacrylic acid) nanosystems for delivery of natural products.

Mashinchian¹,

Salehi²,

Dehghan³

et al. 2010

Int J Drug delivery

View full text Add to dashboard Cite

show abstract

“…Naltrexone was the first drug to receive FDA approval to treat alcohol dependence (4)(5)(6)(7). Because of the extensive first-pass metabolism in the liver, only 5-20 % of the oral dosage of this drug reaches the systemic circulation unchanged (4,8).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, developing a controlled-release parenteral formulation of which a single injection may release the drug over a week, month, or even longer is especially desirable. Early trials have suggested that the sustained release of naltrexone may be appropriate for the management of either alcohol or opioid dependence (5,13,14). There are several systems for the subcutaneous implantation of naltrexone hydrochloride (9,(15)(16)(17), but this route of administration requires intricate technology, and it is too expensive (8).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Investigation of Sustained Drug Delivery Systems Using an Injectable, Thermosensitive, In Situ Forming Hydrogel Composed of PLGA–PEG–PLGA

et al. 2012

View full text Add to dashboard Cite

Abstract. In situ gelling systems are very attractive for pharmaceutical applications due to their biodegradability and simple manufacturing processes. The synthesis and characterization of thermosensitive poly(D,L-lactic-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)-PLGA triblock copolymers as in situ gelling matrices were investigated in this study as a drug delivery system. Ring-opening polymerization using microwave irradiation was utilized as a novel technique, and the results were compared with those using a conventional method of polymerization. The phase transition temperature and the critical micelle concentration (CMC) of the copolymer solutions were determined by differential scanning calorimetry and spectrophotometry, respectively. The size of the micelles was determined with a light scattering method. In vitro drug release studies were carried out using naltrexone hydrochloride and vitamin B12 as model drugs. The rate and yield of the copolymerization process via microwave irradiation were higher than those of the conventional method. The copolymer structure and concentration played critical roles in controlling the sol-gel transition temperature, the CMC, and the size of the nanomicelles in the copolymer solutions. The rate of drug release could be modulated by the molecular weight of the drugs, the concentration of the copolymers, and their structures in the formulations. The amount of release versus time followed zero-order release kinetics for vitamin B12 over 25 days, in contrast to the Higuchi modeling for naltrexone hydrochloride over a period of 17 days. In conclusion, PLGA-PEG1500-PLGA with a lactide-to-glycolide ratio of 5:1 is an ideal system for the long-acting, controlled release of naltrexone hydrochloride and vitamin B12.

show abstract

“…The nanoparticles are separated from the original liquid phase to eliminate the organic solvent(s) and the nonencapsulated drug. Preferably, the filtration is carried out at 25 C with an ultrafiltratio membrane.…”

mentioning

confidence: 99%

“…And, it is possible to conclude that the formation of hydrogel layer at 37 C might act as additional diffusion barrier for the drug release. 19,22,25 CONCLUSIONS Naltrexone was successfully encapsulated into the Poly(NIPAAm-AAm-VP) and its blend with PLGA. The yield of encapsulation of naltrexone in Poly(NIPAAm-AAm-VP) and PLGA (NIPAAm-AAm-VP) was 34-65%.…”

mentioning

confidence: 99%

Thermosensitive nanoparticles prepared from poly(N‐isopropylacrylamide‐acrylamide‐vinilpyrrolidone) and its blend with poly(lactide‐co‐glycolide) for efficient drug delivery system

Salehi

Davaran²,

Rashidi

et al. 2008

J of Applied Polymer Sci

View full text Add to dashboard Cite

Temperature-responsive polymers have become increasingly attractive as carrier for the injectable drug delivery systems. In the present work, we have studied the preparation of poly(N-isopropylacrylamide-acrylamide-vinilpyrrolidone) (NIPAAm-AAm-VP terpolymer) nanoparticulated terpolymer and its blend with poly(lactide-co-glycolide, PLGA; molar ratio of lactide/glycolid 1/3). Thermosensitive terpolymer, poly(NIPAAm-AAm-VP) was prepared by free-radical polymerization in aqueous solution. The nanoparticles of poly(NIPAAm-AAm-VP) and its blend with PLGA containing naltrexone were prepared using the evaporation and w/o emulsion-solvent evaporation methods, respectively. Nanoparticles prepared from terpolymer-PLGA blend at low polymer concentration (5%) shows larger particle size (>300 nm) and higher drug content%. Various types of nanoparticles showed a burst release of less than 10% after 24 h. The results suggest that by regulating different variables, desired release profiles of naltrexone can be achieved using a blend of PLGA-poly(NIPAAm-AAm-VP) nanoparticulate system.

show abstract

Design of naltrexone-loaded hydrolyzable crosslinked nanoparticles

Cited by 39 publications

References 20 publications

Novel thermosensitive poly (N-isopropylacrylamide-co-vinylpyrrolidone-co-methacrylic acid) nanosystems for delivery of natural products.

Novel thermosensitive poly (N-isopropylacrylamide-co-vinylpyrrolidone-co-methacrylic acid) nanosystems for delivery of natural products.

Preparation and Investigation of Sustained Drug Delivery Systems Using an Injectable, Thermosensitive, In Situ Forming Hydrogel Composed of PLGA–PEG–PLGA

Thermosensitive nanoparticles prepared from poly(N‐isopropylacrylamide‐acrylamide‐vinilpyrrolidone) and its blend with poly(lactide‐co‐glycolide) for efficient drug delivery system

Contact Info

Product

Resources

About