Design of Novel Oligomeric Mixed Ligand Complexes: Preparation, Biological Applications and the First Example of Their Nanosized Scale

Abstract

A successful oligomerization of ternary metal complexes, cobalt (II), nickel (II), copper (II), zinc (II), chromium (III) and ferric sulfate (III) with nitrilotriacetic acid (NTA) as a primary ligand and glutamic acid as a secondary ligand, has been demonstrated. The formation of oligomers arose from the presence of the sulfate moiety, which operates as a bridged bidentate ligand that coordinates with other metal moieties. The novel oligomers exhibited octahedral structures, which bonded together through the sulfate moiety. In silico predictions were conducted to gauge the bioactivity, physico-chemical and pharmacokinetic properties. The biological activities of these oligomers as well as their tumor inhibitory behavior have been explored. This work also presents a facile and novel method of preparing these materials in nanosize, using Cetyltrimethylammonium bromide (CTAB) and polyvinyl alcohol (PVA) as capping ligands. The size and shape of the nanomaterials have been confirmed using the transmission electron microscope (TEM) and the scanning electron microscope (SEM).

Synthesis, characterization and antibacterial study of Co(II) and Cu(II) complexes of mixed ligands of piperaquine and diclofenac

“…In a similar pattern, Pip, a nitrogen-based ligand, shows coordination to the metal ions through the amine N and the Cl as evidenced by the disappearance of the band 3286 cm -1 attributable to the amine N with Δ value of 147 cm -1 , and also the hypsochromic shift of C-Cl band at 650 cm -1 in the ligand to 662 cm -1 in the metal complexes, indicating the possibility of coordination through the Cl group. These rationally suggest the ligand to act as a bidentate ligand (16) The electronic spectra, magnetic moment, and elemental analysis results of the synthesized metal complexes are reported in Table 3 (17,30,31). The presence of the ligands in the complexes as proposed (Schemes 1 & 2) was supported with good consistency between the CHNS elemental analysis results (Supplementary file) and the suggested molecular formulas.…”

“…Therefore, this study aims at the preparation of coordination compounds consisting of Co(II) and Cu(II) ions in complex with sodium NaD and Pip as mixed ligands using solvent-based inorganic synthetic approach, characterization and evaluation of antioxidant and antibacterial activity in vitro as well as some in silico biological studies, while adopting some reported protocols (10,(14)(15)(16)(17)(18) with modifications.…”

“…The physicochemical and pharmacokinetics profiles of the complexes were predicted in terms of adsorption, distribution, metabolism, excretion and toxicity (ADMET) using the web-based Swiss ADME computational tools by inputting the SMILES file of each complex (17,22). The properties further reveal the drug-likeness of the molecules under study.…”

Determination of amino acids of some plants from Gentianaceae family

“…in the greatest amount, their content was 1.56 μg/mg (1.29% from total content amino acids), 1.16 μg/mg (0.96%) and 0.92 μg/mg (0.76%), respectively. L-glutamic acid participates in many metabolic reactions, is a source of glucose, and holds its level in the blood (Okasha et al 2019). Also, this acid is used as a conjugate because its effectiveness of anticancer medicine is better and reductions of its toxicity in attitude to normal cells.…”

Heteroleptic Metal Complexes of a Pyrimidinyl Based Schiff Base Ligand Incorporating 2,2′-Bipyridine Moiety: Synthesis, Characterization, and Biological Studies

“…In addition to the improved biological properties of chelates over their precursor ligands, chelation also leads to formation of a more stable metal-organic framework. The choice of the metal connectors and the bridging ligands permits the utilization of these materials in areas, such as ion exchange, adsorption and separation processes; heterogeneous and biomimetic catalysis; sensor technologies; luminescence; drug delivery; and proton conductivity (Okasha et al, 2019). The metal-organic coordination macromolecules exhibit remarkable stability in comparison to their discrete complexes due to their macrocycle or chelate effect.…”