Design of Porous, Core-Shell, and Hollow Nanofibers

Yousefzadeh, Maryam; Ghasemkhah, Farzaneh

doi:10.1007/978-3-319-53655-2_9

Cited by 5 publications

(3 citation statements)

References 131 publications

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“…Coaxial electrospinning is a modified conventional electrospinning to produce micro/nanofibers with core–shell architecture . In this process, at least two fluids are independently fed through a coaxial nozzle comprising inner/outer orifice and drawn to fabricate core–shell structured fibers.…”

Section: Introductionmentioning

confidence: 99%

Potential core–shell designed scaffolds with a gelatin‐based shell in achieving controllable release rates of proteins for tissue engineering approaches

Ghasemkhah

Latifi

Hadjizadeh

et al. 2019

J Biomedical Materials Res

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The biomaterials design as core–shell structures opens a new door to the release of susceptible biomolecules in a controllable manner and enables to place natural biomaterials as shell layers to impart the effective biofunctional features at surfaces. In this study, core–shell designed scaffolds were prepared using coaxial electrospinning with hybrid of gelatin (GT)/polycaprolactone (PCL) at different weight ratios as their shell and protein solution as their core, followed by cross‐linking to impart controllable release rates, tunable mechanical properties, and enhanced cytocompatibility. SEM, FM, and TEM confirmed the successful production of uniform core–shell nanofibers and homogeneous protein distribution. Results showed that an increase in GT proportion in the shell resulted in a decrease in fiber diameter, an increase of Young's modulus, and an intense burst release of BSA 0.2% which could be controlled through cross‐linking. The mechanical tests revealed that the GT/PCL combining and cross‐linking improved mechanical properties which correlated with an increase in spreading and proliferation of HUVECs. A slight burst release was also detected from BSA 0.05% and EGF encapsulated GT73P‐cross‐linked scaffold which demonstrated their applicability for a controlled release of dilute proteins. We were able to successfully incorporate two types of protein with different concentrations without supporting polymer into the GT shell to provide scaffolds possessing tunable mechanical properties and controllable release rates through blending with PCL at different ratios and/or cross‐linking. These findings are promising to promote delivery systems of angiogenic growth factors that are needed a sustained release with different rates at each angiogenesis stage. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

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Section: Introductionmentioning

confidence: 99%

Potential core–shell designed scaffolds with a gelatin‐based shell in achieving controllable release rates of proteins for tissue engineering approaches

Ghasemkhah

Latifi

Hadjizadeh

et al. 2019

J Biomedical Materials Res

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“…Intimate contact between the MOS nanocrystals is achieved in the composite nanofibers [130][131][132][133]. Another method uses the coaxial-electrospinning configuration [84,134], for which polymer solutions are prepared with each of the inorganic precursors separately. The solution with the precursor of the main metal oxide leaves the spinneret through a central circular nozzle, while the solution with the precursor of the second metal oxide exits the spinneret through an annular nozzle that surrounds and is concentric to the circular nozzle, as depicted in Figure 10a) [135].…”

Section: Functionalization Of 1d Metal Oxide Nanostructuresmentioning

confidence: 99%

One-Dimensional Metal Oxide Nanostructures for Chemical Sensors

Hontañón¹,

Vallejos²

2022

21st Century Nanostructured Materials - Physics, Chemistry, Classification, and Emerging Applications in Industry, Biomedicine,

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The fabrication of chemical sensors based on one-dimensional (1D) metal oxide semiconductor (MOS) nanostructures with tailored geometries has rapidly advanced in the last two decades. Chemical sensitive 1D MOS nanostructures are usually configured as resistors whose conduction is altered by a charge-transfer process or as field-effect transistors (FET) whose properties are controlled by applying appropriate potentials to the gate. This chapter reviews the state-of-the-art research on chemical sensors based on 1D MOS nanostructures of the resistive and FET types. The chapter begins with a survey of the MOS and their 1D nanostructures with the greatest potential for use in the next generation of chemical sensors, which will be of very small size, low-power consumption, low-cost, and superior sensing performance compared to present chemical sensors on the market. There follows a description of the 1D MOS nanostructures, including composite and hybrid structures, and their synthesis techniques. And subsequently a presentation of the architectures of the current resistive and FET sensors, and the methods to integrate the 1D MOS nanostructures into them on a large scale and in a cost-effective manner. The chapter concludes with an outlook of the challenges facing the chemical sensors based on 1D MOS nanostructures if their massive use in sensor networks becomes a reality.

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“…Among the available techniques, electrospinning is one of the most promising methods of manufacturing nanofiber membranes in tissue engineering applications [7]. Electrospinning is an effective nanofiber fabrication process that stretches unfragmented polymer fibers from a polymer solution or polymer melt with electrostatic force using a high voltage direct current in the form of a liquid jet preparation of nanofibers [8,9]. As ideal wound dressings, electrospun nanofiber membranes have a similar structure to an extracellular matrix (ECM), which can promote the interaction between cells at the wound surface.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Properties of (Sc2O3-MgO)/Pcl/Pvp Electrospun Nanofiber Membranes for the Inhibition of Escherichia coli Infections

Liu

et al. 2023

IJMS

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Due to their high porosity, large specific surface area, and structural similarity with the extracellular matrix (ECM), electrospun nanofiber membranes are often endowed with the antibacterial properties for biomedical applications. The purpose of this study was to synthesize nano-structured Sc2O3-MgO by doping Sc3+, calcining at 600 °C, and then loading it onto the PCL/PVP substrates with electrospinning technology with the aim of developing new efficient antibacterial nanofiber membranes for tissue engineering. A scanning electron microscope (SEM) and energy dispersive X-ray spectrometer (EDS) were used to study the morphology of all formulations and analyze the types and contents of the elements, and an X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Fourier transform attenuated total reflection infrared spectroscopy (ATR-FTIR) were used for further analysis. The experimental results showed that the PCL/PVP (SMCV-2.0) nanofibers loaded with 2.0 wt% Sc2O3-MgO were smooth and homogeneous with an average diameter of 252.6 nm; the antibacterial test indicated that a low load concentration of 2.0 wt% Sc2O3-MgO in PCL/PVP (SMCV-2.0) showed a 100% antibacterial rate against Escherichia coli (E. coli).

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Design of Porous, Core-Shell, and Hollow Nanofibers

Cited by 5 publications

References 131 publications

Potential core–shell designed scaffolds with a gelatin‐based shell in achieving controllable release rates of proteins for tissue engineering approaches

Potential core–shell designed scaffolds with a gelatin‐based shell in achieving controllable release rates of proteins for tissue engineering approaches

One-Dimensional Metal Oxide Nanostructures for Chemical Sensors

Preparation and Properties of (Sc2O3-MgO)/Pcl/Pvp Electrospun Nanofiber Membranes for the Inhibition of Escherichia coli Infections

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