The bionic flapping-wing aircraft has the advantages of high flexibility and strong concealment; however, in the existing flapping-wing aircraft, the platform performance is influenced by the payload capacity, endurance, and durability; additionally, the mission capability is constrained, making it challenging to put into use in real-world scenarios. In response to this issue, this article offers a thorough design approach for a large-span flapping-wing aircraft, focusing on effective flapping wings, effective flapping mechanism design, and enhancement of flapping mechanism reliability, and ultimately realizing the design and verification of a new bionic flapping-wing aircraft with a large wingspan, called “Cloud Owl”. It has a wingspan of 1.82 m and weighs 980 g. The aircraft is capable of autonomous flight and remote control, and it can carry a range of mission-specific equipment. More than 200 flights have been made by “Cloud Owl” so far in Xi’an, Beijing, Tianjin, Tibet, Ganzi, and other places. It has evolved into a flapping-wing aircraft platform with exceptional stability, payload capacity, and long endurance.