Design of Self-Assembling Peptides and Their Biomedical Applications

Abstract

Lecithin-chitosan nanoparticles are a promising carrier for topical delivery of quercetin.

Sustained release of hepatocyte growth factor by cationic self-assembling peptide/heparin hybrid hydrogel improves β-cell survival and function through modulating inflammatory response

“…It was well documented that SAPs rarely showed toxicity and immune response in various cell and animal experiments because they were prepared from natural amino acids. 12,13 Our results also indicated that cationic SAP was a biocompatible nanomaterial to deliver bioactive cargos to β-cells.…”

“…2,3 SAP could serve as a flexible platform to deliver various chemical drugs and bioactive proteins. 12,15,16 In this study, we fabricated a cationic SAP/ Hep hybrid gel to deliver HGF and evaluated its protective effect on β-cell in transplantation. KLD12 is an ionic-complementary peptide that contains positively charged lysines and negatively charged aspartic acids, and the net charge is zero.…”

“…12,13 Some SAPs could self-assemble to nanofibers and further change to hydrogels under physiological saline conditions. SAPs had been widely used in various biomedical applications including cell culture, tissue engineering, and drug delivery.…”

“…SAPs had been widely used in various biomedical applications including cell culture, tissue engineering, and drug delivery. [12][13][14][15] RADA16 peptide was used to release smallmolecule compounds and GFs, and the results showed that these molecules rapidly diffused through the hydrogel and resulted in a fast release of GFs. 16,17 Therefore, improved SAP for slow release of small-molecule compounds and GFs is needed.…”

Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs

“…[13][14][15] Several wellstudied materials have been developed into clinically available formulations, such as Abraxane ® and Doxil ® . 16,17 At the same time, a category of self-assembling peptides as novel nanomaterials has emerged in the past decade with advanced properties in 18,19 Based on their chemical structures, selfassembling peptides could form different nanostructures including nanoparticles, nanotubes, and nanofibers, which are also potential carriers for drug delivery. [20][21][22][23][24][25][26] It has been demonstrated that nanostructures with a high aspect ratio are advantageous as drug carriers; 27,28 however, on the other hand, their drug loading capacity (LC) is usually very low, 24,29 which has hampered the development of a drug delivery system based on these nanomaterials.…”