Design of Smart Oligo(ethylene glycol)-Based Biocompatible Hybrid Microgels Loaded with Magnetic Nanoparticles

Boularas, Mohamed; Gombart, Emilie; Tranchant, Jean‐François; Billon, Laurent; Save, Maud

doi:10.1002/marc.201400578

Cited by 33 publications

(27 citation statements)

References 37 publications

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“…A triblock-engineered polypeptide was immobilized on the surface of gold nanorods by electrostatic adsorption. Likewise, Boularas and his research team [153,154] demonstrated the successful formation of microgels with oligoethylenglycol methacrylate (OEG) monomers together with the physical incorporation of Fe 2 O 3 NPs. They were synthesized by conventional precipitation-polymerization and their sizes were approximately 500 nm.…”

Section: Hybrid Nanogelsmentioning

confidence: 99%

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

2018

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Hybrid nanomaterials based on inorganic nanoparticles and polymers are highly interesting structures since they combine synergistically the advantageous physical-chemical properties of both inorganic and polymeric components, providing superior functionality to the final material. These unique properties motivate the intensive study of these materials from a multidisciplinary view with the aim of finding novel applications in technological and biomedical fields. Choosing a specific synthetic methodology that allows for control over the surface composition and its architecture, enables not only the examination of the structure/property relationships, but, more importantly, the design of more efficient nanodevices for therapy and diagnosis in nanomedicine. The current review categorizes hybrid nanomaterials into three types of architectures: core-brush, hybrid nanogels, and core-shell. We focus on the analysis of the synthetic approaches that lead to the formation of each type of architecture. Furthermore, most recent advances in therapy and diagnosis applications and some inherent challenges of these materials are herein reviewed.

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Section: Hybrid Nanogelsmentioning

confidence: 99%

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

2018

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“…) were prepared by loading preformed MNPs into thermoresponsive oligo(ethylene glycol) methacrylate based nanogels as described by Boularas et al 28 . Briefly, for encapsulating the MNPs into nanogels, the pH of 5 mL of NanoGels solution…”

Section: Encapsulation Of Magnetic Nanoparticles Into Nanogelsmentioning

confidence: 99%

“…Boularas et al 28 Q depends on the degree of crosslinking of polymer matrix and is directly related to the quantity of water that it can be loaded and released by nanogels. The swelling ratio remains the same for non-magnetic nanogels at pH 5.5 and pH 7.5 (Q = 1.7), but it decreases from Q = 3.7 to 1.6 for MagNanoGels-37.5 wt% when the pH increases from 5.5 to 7.5.…”

Section: Synthesis and Characterization Of Magnanogelsmentioning

confidence: 99%

Doxorubicin Intracellular Remote Release from Biocompatible Oligo(ethylene glycol) Methyl Ether Methacrylate-Based Magnetic Nanogels Triggered by Magnetic Hyperthermia

Cazares-Cortes

Espinosa

Guigner

et al. 2017

ACS Appl. Mater. Interfaces

114

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Hybrid nanogels, composed of thermoresponsive polymers and superparamagnetic nanoparticles, are attractive nanocarriers for biomedical applications, being able-as a polymer matrix-to uptake and release high quantities of chemotherapeutic agents and-as magnetic nanoparticles-to be heated when exposed to an alternative magnetic field (AMF), better known as magnetic hyperthermia. Herein, biocompatible, pH-responsive, magnetoresponsive, and thermoresponsive nanogels, based on oligo(ethylene glycol) methyl ether methacrylate monomers and a methacrylic acid comonomer were prepared by conventional precipitation radical copolymerization in water, post-assembled by complexation with iron oxide magnetic nanoparticles (MNPs) of maghemite (γ-FeO), and loaded with an anticancer drug (doxorubicin, DOX), for remotely controlled drug release by a "hot spot", as an athermal magnetic hyperthermia strategy against cancer. These nanogels, denoted MagNanoGels, with a hydrodynamic diameter from 328 to 460 nm, as a function of the MNP content, have a swelling-deswelling behavior at their volume phase temperature transition around 47 °C in a physiological medium (pH 7.5), which is above the human body temperature (37 °C). Applying an alternative magnetic field increases the release of DOX by 2-fold, while no macroscopic heating was recorded. This enhanced drug release is due to a shrinking of the polymer network by local heating, as illustrated by the MagNanoGel size decrease under an AMF. In cancer cells, not only do the DOX-MagNanoGels internalize DOX more efficiently than free DOX, but also DOX intracellular release can be remotely triggered under an AMF, in athermal conditions, thus enhancing DOX cytotoxicity.

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“…Depending on the composition they can be sensitive to external conditions (temperature, pH, magnetic field, light) making them systems of interest for potential applications in numerous fields, namely: drug delivery systems, sensors, catalysis, chemical separation and enzyme immobilization [4][5][6][7][8][9][10][11][12][13]. The swelling/deswelling mechanism of microgels is driven by the free energy changes related to polymer/solvent system and is directly connected to its network elasticity (Flory-Rhener theory) [14,15].…”

Section: Introductionmentioning

confidence: 99%

One-pot synthesis of dual-stimuli responsive hybrid PNIPAAm-chitosan microgels

et al. 2015

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Design of Smart Oligo(ethylene glycol)-Based Biocompatible Hybrid Microgels Loaded with Magnetic Nanoparticles

Cited by 33 publications

References 37 publications

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

Doxorubicin Intracellular Remote Release from Biocompatible Oligo(ethylene glycol) Methyl Ether Methacrylate-Based Magnetic Nanogels Triggered by Magnetic Hyperthermia

One-pot synthesis of dual-stimuli responsive hybrid PNIPAAm-chitosan microgels

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