2014
DOI: 10.3109/10717544.2014.903011
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Design of solid lipid nanoparticles for caffeine topical administration

Abstract: Caffeine is an interesting compound showing anticancer and protective effects upon topical administration, although its penetration through the skin is compromised by its hydrophilicity. Materials and methods: SLN-CAF were formulated by using a modification of the quasi-emulsion solvent diffusion technique (QESD) and characterized by PCS and DSC analyses. In vitro percutaneous absorption studies were effected using excised human skin membranes (i.e. Stratum Corneum Epidermis or SCE).Results: SLN-CAF were in a … Show more

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Cited by 56 publications
(27 citation statements)
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“…It is considered that cationic NPs present within a lysosome undergoing acidification may accumulate protons entering via the proton pump, therefore, acting as a ''proton sponge'' and maintaining the pump active, resulting in osmotic swelling, lysis, and release of the lysosome content into the cytoplasm. The ability of encapsulating and loading of drugs is quite important for the delivery systems (Puglia et al, 2016). The good DL efficiency of carriers along with the suitable release behavior of the system could bring about high anti-tumoral activity to the delivery system (Frungillo et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…It is considered that cationic NPs present within a lysosome undergoing acidification may accumulate protons entering via the proton pump, therefore, acting as a ''proton sponge'' and maintaining the pump active, resulting in osmotic swelling, lysis, and release of the lysosome content into the cytoplasm. The ability of encapsulating and loading of drugs is quite important for the delivery systems (Puglia et al, 2016). The good DL efficiency of carriers along with the suitable release behavior of the system could bring about high anti-tumoral activity to the delivery system (Frungillo et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…The measurements were determined at 25°C in triplicate. During the experiment, refractive index of the samples always matched the liquid (toluene) to avoid stray light (Puglia et al, 2016).…”
Section: Sln Characterizationmentioning
confidence: 99%
“…[ 34] In other study, Hamishehkar (2015), Caffeine-loaded SLNs were prepared by hot homogenization technique using Precirol® as lipid phase. The mean particle size and encapsulation efficiency for optimized SLN formulation were 94 nm and 86%, respectively.…”
Section: Design Of Solid Lipid Nanoparticles For Hydrophilic Drugs Tomentioning
confidence: 99%
“…Percentage of activity by SLN dispersions through rat skin was 13 folds more than the control. [43] The Table 1 [34] Caffeine Modification of the quasiemulsion solvent diffusion technique Good encapsulation efficacy (75% ± 1.1) and a well-determined size distribution (182.6 ± 8.4 nm). [35] Caffeine Hot Homogenization Technique Mean particle size: 94 nm and encapsulation efficiencies: 86%.…”
Section: Design Of Solid Lipid Nanoparticles For Hydrophilic Drugs Tomentioning
confidence: 99%