This paper presents a method to design a static output feedback active suspension controller for ride comfort improvement and motion sickness reduction in a real vehicle system. Full-state feedback controller has shown good performance for active suspension control. However, it requires a lot of states to be measured, which is very difficult in real vehicles. To avoid this problem, a static output feedback (SOF) controller is adopted in this paper. This controller requires only three sensor outputs, vertical velocity, roll and pitch rates, which are relatively easy to measure in real vehicles. Three types of SOF controller are proposed and optimized with linear quadratic optimal control and the simulation optimization method. Two of these controllers have only three gains to be tuned, which are much smaller than those of full-state feedback. To validate the performance of the proposed SOF controllers, a simulation is carried out on a vehicle simulation package. From the results, the proposed SOF controllers are quite good at improving ride comfort and reducing motion sickness.