2022
DOI: 10.1021/acs.inorgchem.2c03451
|View full text |Cite
|
Sign up to set email alerts
|

Design Principles of Responsive Relaxometric 19F Contrast Agents: Evaluation from the Point of View of Relaxation Theory and Experimental Data

Abstract: 19 F magnetic resonance imaging (MRI) is a promising tool in medical diagnostics. An important class of 19 F MRI contrast agents is based on paramagnetic resonance enhancement. This effect allows an improvement in sensitivity by increasing the number of scans per unit of time or facilitates the development of responsive contrast agents that are based on changes in relaxation rates as a detection principle. In this work, Bloch− Redfield−Wangsness relaxation theory was used to predict the relaxation properties … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
13
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
4
1

Relationship

1
4

Authors

Journals

citations
Cited by 5 publications
(14 citation statements)
references
References 94 publications
1
13
0
Order By: Relevance
“…The observed distances are relevant for their significant influence on the relaxation times. 30 As the trifluoroethyl group undergoes free rotation, mean distances (Table 3) are used in the following discussion, although effective distances in the solution can differ due to molecular flexibility and can be shorter. 30 Solutions of the prepared complexes underwent detailed 19 F NMR study.…”
Section: F Nmr Relaxation Of the Complexesmentioning
confidence: 99%
See 2 more Smart Citations
“…The observed distances are relevant for their significant influence on the relaxation times. 30 As the trifluoroethyl group undergoes free rotation, mean distances (Table 3) are used in the following discussion, although effective distances in the solution can differ due to molecular flexibility and can be shorter. 30 Solutions of the prepared complexes underwent detailed 19 F NMR study.…”
Section: F Nmr Relaxation Of the Complexesmentioning
confidence: 99%
“…30 As the trifluoroethyl group undergoes free rotation, mean distances (Table 3) are used in the following discussion, although effective distances in the solution can differ due to molecular flexibility and can be shorter. 30 Solutions of the prepared complexes underwent detailed 19 F NMR study. The T 1 and T * 2 relaxation times were measured at available magnetic fields (7.05/9.40/14.1 T, 282/376/565 MHz) at 25 and 37 °C and the results are outlined in Table 4.…”
Section: F Nmr Relaxation Of the Complexesmentioning
confidence: 99%
See 1 more Smart Citation
“…The selection of the most suitable paramagnetic ion for complexation was conducted by theoretical calculations based on the Bloch–Redfield–Wangsness (BRW) theory, taking into account the electron–nucleus dipole–dipole and Curie interactions only. This was justified by an earlier review of available 19 F relaxation data for DOTA-derived paramagnetic complexes . The highest relaxation time differences from pH-induced isomerization resulted from complexes of Gd­(III), Ho­(III), Dy­(III), Er­(III), Cu­(II), or Cr­(III) (Figure S18 and Table S1).…”
Section: Resultsmentioning
confidence: 92%
“…This was justified by an earlier review of available 19 F relaxation data for DOTA-derived paramagnetic complexes. 52 The highest relaxation time differences from pHinduced isomerization resulted from complexes of Gd(III), Ho(III), Dy(III), Er(III), Cu(II), or Cr(III) (Figure S18 and Table S1).…”
Section: -Triyl)triacetic Acid]-(2e)-(pyridin-2-yl)-{2-[3-(trifluorom...mentioning
confidence: 99%