Design, Simulation, Modeling, and Implementation of a Square Helmholtz Coil in Contrast with a Circular Coil for MRI Applications

Ghaly, S. M. A.; Khan, Mohammad Obaidullah

doi:10.48084/etasr.3171

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…MD simulations help us understand the atomic movements of proteins and protein–ligand complexes. , MD simulation studies were used to confirm docking results of interactions between PTP-1B and the selected bioactive constituent epicatechin. The structural coordinates of the thermodynamically stable systems of free PTP-1B and its interactions with the selected compound epicatechin were authenticated by MD simulation using GROMACS v5.5.1 .…”

Section: Methodsmentioning

confidence: 99%

In Silico Analysis of PTP1B Inhibitors and TLC-MS Bioautography-Based Identification of Free Radical Scavenging and α-Amylase Inhibitory Compounds from Heartwood Extract of Pterocarpus marsupium

et al. 2022

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Type 2 diabetes mellitus leads to metabolic impairment caused by insulin resistance and hyperglycemia, giving rise to chronic diabetic complications and poor disease prognosis. The heartwood of Pterocarpus marsupium has been used in Ayurveda for a long time, and we sought to find the actual mechanism(s) driving its antidiabetic potential. Methanol was used to prepare the extract using a Soxhlet extraction, and the identification of metabolites was performed by thin-layer chromatography (TLC) and ultraperformance-liquid chromatography and mass spectroscopy (UP-LCMS). The antioxidant potential of methanolic heartwood extract of Pterocarpus marsupium MHPM was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and a reducing power assay. The α-amylase and α-glucosidase enzyme inhibitory potential of MHPM were investigated for their antidiabetic activity against acarbose. TLC-MS-bioautography was performed to identify the compounds responsible for possible antioxidant and antidiabetic activities. Moreover, targeting protein tyrosine phosphatase 1B (PTP1B), a key regulator of insulin resistance, by identified metabolites from MHPM through molecular docking and all-atom molecular dynamics (MD) simulations was also undertaken, suggesting its potential as an antidiabetic herb. The IC50 of free-radical scavenging activity of MHPM against DPPH was 156.342 ± 10.70 μg/mL. Further, the IC50 values of MHPM in α-amylase and α-glucosidase enzymatic inhibitions were 158.663 ± 10.986 μg/mL and 180.21 ± 11.35 μg/mL, respectively. TLC-MS-bioautography identified four free radical scavenging metabolites, and vanillic acid identified by MS analysis showed both free radical scavenging activity and α-amylase inhibitory activity. Among the identified metabolites from MHPM, epicatechin showed significant PTP1B docking interactions, and its MD simulations revealed that PTP1B forms a stable protein–ligand complex with epicatechin throughout the progression, which indicates that epicatechin may be used as a promising scaffold in the development of the antidiabetic drug after isolation from Pterocarpus marsupium. Overall, these findings imply that Pterocarpus marsupium is a source of valuable metabolites that are accountable for its antioxidant and antidiabetic properties.

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Section: Methodsmentioning

confidence: 99%

In Silico Analysis of PTP1B Inhibitors and TLC-MS Bioautography-Based Identification of Free Radical Scavenging and α-Amylase Inhibitory Compounds from Heartwood Extract of Pterocarpus marsupium

et al. 2022

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“…Each single loop has a semi-axial dimension x 1 and y 1 . To analyze this situation, a formula for the field produced around the origin (x = y = z = 0) by any loop traversed by a current I and of declination with respect to Oz is proposed [13][14]:…”

Section: Calculation Of the B 1 Magnetic Fieldmentioning

confidence: 99%

Design and Testing of a Radiofrequency Ellipsoidal Helmholtz Coil in Contrast with a Circular Pair for Nuclear Magnetic Resonance

Al-Snaie

2023

Eng. Technol. Appl. Sci. Res.

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The design and testing of a Helmholtz prototype probe with a relatively homogeneous radiofrequency field that can be used for MRI are presented in this paper. It consists of two coaxial separately tuned ellipsoidal rings of wire in a symmetric arrangement. The developed ellipsoidal structure is tested experimentally in free space and is compared with the results obtained with an equivalent circular standard Helmholtz coil. Complete electrical modeling of the coils taking into account all couplings (inductive and capacitive) is studied. The proposed ellipsoidal Helmholtz coil provides better performance in terms of field homogeneity, efficiency, and quality factor. The width of the lobe at 10% for the ellipsoidal coil is 20% bigger. Moreover, a significant improvement in the quality factor is observed in free space. Also, the efficiency is increased by 37%. Finally, the Signal to Noise Ratio (SNR) of the ellipsoidal coil is higher than that of the circular coil.

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“…The arrangement of coils is usually introduced in the textbook section on sources of magnetic field because of its variety of applications (for a detailed description see e.g. [10][11][12][13][14][15][16]). In fact, they play an important role in industry, medical equipment and material characterization, since they can produce an uniform magnetic field in a small region of space.…”

Section: Magnetic Field Due To Coil Configurationsmentioning

confidence: 99%

Exploring the magnetic field of Helmholtz and Maxwell coils: a computer-based approach exploiting the superposition principle

García-Farieta

Márquez

2020

Rev. Bras. Ensino Fís.

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Teaching magnetism is one of the most challenging topics at undergraduate level in programmes with scientific background. A basic course includes the description of the magnetic interaction along with empirical results such as the Biot-Savart law's. However, evaluating the magnetic field due to certain current carrying system at any point in space is not an easy task, especially for points in space where symmetry arguments cannot be applied. In this paper we study the magnetic field produced by both Helmholtz and Maxwell coils at all points in space by using a hybrid methodology that combines the superposition principle and an analytical result. We implement a computational approach, that is based on iterating n times the magnetic field produced by a finite current-carrying wire, to evaluate the magnetic field at any point in space for coils arrangements without using advanced calculus. This methodology helps teachers and students to explore the field due to systems with different levels of complexity, combining analytical and computational skills to visualize and analyse the magnetic field. After our analysis, we show that this is an useful approach to emphasize fundamental concepts and mitigate some of the issues that arise when evaluating the magnetic field for systems proposed in introductory physics textbooks.

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Design, Simulation, Modeling, and Implementation of a Square Helmholtz Coil in Contrast with a Circular Coil for MRI Applications

Cited by 7 publications

References 19 publications

In Silico Analysis of PTP1B Inhibitors and TLC-MS Bioautography-Based Identification of Free Radical Scavenging and α-Amylase Inhibitory Compounds from Heartwood Extract of Pterocarpus marsupium

In Silico Analysis of PTP1B Inhibitors and TLC-MS Bioautography-Based Identification of Free Radical Scavenging and α-Amylase Inhibitory Compounds from Heartwood Extract of Pterocarpus marsupium

Design and Testing of a Radiofrequency Ellipsoidal Helmholtz Coil in Contrast with a Circular Pair for Nuclear Magnetic Resonance

Exploring the magnetic field of Helmholtz and Maxwell coils: a computer-based approach exploiting the superposition principle

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