Design, solvent free synthesis, and antimicrobial evaluation of 1,4 dihydropyridines

Murthy, Y. L. N.; Rajack, Abdul; Ramji, M. Taraka; babu, J. Jeson; Praveen, Ch.; Lakshmi, K. S.

doi:10.1016/j.bmcl.2012.05.003

Cited by 72 publications

(20 citation statements)

References 44 publications

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“…Murthy et al., in 2012 performed the docking studies of [ Scheme (34‐38)] analogue structures of 1,4‐DHP and it was found that analogue with β‐ketoester ( 38 ) has more binding affinity towards (KcsA) potassium receptor, to validate the docking results thirteen derivatives ( 38 a‐m ) of same series were synthesized using eco‐friendly cellulose sulfuric acid as catalyst at 100 0 C for 2–5 hrs under solvent free conditions. All the thirteen synthesized derivatives were evaluated for antimicrobial activity out of which four with (R= 2‐Cl, 3‐OH, 2‐OH and 4‐OH, 3‐OMe ) substitution found to be very effective bactericide when tested against ten bacterial species and same results were supported and confirmed by the in‐silico studies suggesting that these had high binding affinity …”

Section: Introductionmentioning

confidence: 61%

Effect of Substitutions on 1, 4‐Dihdropyridines to Achieve Potential Anti‐Microbial Drugs: A Review

2019

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1,4‐Dihydropyridines shows good to excellent activity against various microbial strains and their activity can be moulded to the desired extent. Electron withdrawing aromatic groups at position C‐4, esters on C‐3 & C‐5, and small alkyl groups on C‐2 & C‐6 are the best substitutions to achieve potent anti‐microbial drug. Understanding this concept a new age anti‐microbial agents can be synthesized with next level of potency.

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Section: Introductionmentioning

confidence: 61%

Effect of Substitutions on 1, 4‐Dihdropyridines to Achieve Potential Anti‐Microbial Drugs: A Review

2019

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“…An efficient methodology for the synthesis of 4-aryl-1,4-dihydropyridines in excellent yield under solvent-free condition through the three components condensation of various aldehydes, ethyl acetoacetate and ammonium acetate (NH 4 OAc) at 100 o C, have been established by Murthy et al 25 (Scheme 2). The authors have employed this reaction with various solvents such as methanol, ethanol, acetonitrile, toluene, dioxane and tetrahydrofuran (THF).…”

Section: Methodsmentioning

confidence: 99%

Cellulose sulfuric acid (CSA) and starch sulfuric acid (SSA) as solid and heterogeneous catalysts in green organic synthesis: recent advances

Vekariya¹,

Patel²

2015

Arkivoc

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The use of heterogeneous solid acid catalysts is important to the development of sustainable chemical processes. To this end, cellulose sulfuric acid (CSA) and starch sulfuric acid (SSA) have been developed and used for a wide range of organic transformations, including the synthesis of pharmaceutically important heterocyclic compounds. These heterogeneous catalysts are easily recovered and reused several times without loss of their activity. In this review, we mainly summarize applications of these catalysts in synthetic organic chemistry.

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“…Compounds derived from xanthenes and 1,4-dihydropyridines (1,4-DHPs), such as 1,8-dioxo-octahydroxanthenes and 1,8-dioxodecahydroacridines, are of importance as they have various biological activities such as antibacterial [25], antiinflammatory [26], antimicrobial [27], antitubercular [28], neuroprotectant [29], and insecticidal activities [30]. A number of xanthenes found uses in laser technologies [31], dyes [32], and fluorescent materials for visualization of biomolecules [33].…”

Section: Introductionmentioning

confidence: 99%

Extraordinary catalytic activity of a Keplerate-type giant nanoporous isopolyoxomolybdate in the synthesis of 1,8-dioxo-octahydroxanthenes and 1,8-dioxodecahydroacridines

2014

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NH 4 ) 42 [Mo 72 VI Mo 60 V O 372 (CH 3 COO) 30 (H 2 O) 72 ], a Keplerate-type giant nanoporous isopolyoxomolybdate, denoted as ({Mo 132 }), was found to have extraordinary catalytic activity in the synthesis of 1,8-dioxo-octahydroxanthenes, and 1,8-dioxodecahydroacridines via one-pot reactions. The catalyst was prepared using inexpensive and readily available materials and characterized using FT-IR, and UV spectra. The desired products were obtained only within a few seconds in high yields under solvent-free conditions at 130°C. Furthermore, the procedures and work-ups were simple and the catalyst can be conveniently recovered and reused. To our knowledge, the catalyst exhibits the highest activity over other procedures available in the literature for the synthesis of the mentioned compounds.

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Design, solvent free synthesis, and antimicrobial evaluation of 1,4 dihydropyridines

Cited by 72 publications

References 44 publications

Effect of Substitutions on 1, 4‐Dihdropyridines to Achieve Potential Anti‐Microbial Drugs: A Review

Effect of Substitutions on 1, 4‐Dihdropyridines to Achieve Potential Anti‐Microbial Drugs: A Review

Cellulose sulfuric acid (CSA) and starch sulfuric acid (SSA) as solid and heterogeneous catalysts in green organic synthesis: recent advances

Extraordinary catalytic activity of a Keplerate-type giant nanoporous isopolyoxomolybdate in the synthesis of 1,8-dioxo-octahydroxanthenes and 1,8-dioxodecahydroacridines

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