Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group

Abstract

In previous studies undertaken by our group, a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols (1a–r), which were analogs of fluconazole, was designed and synthesized by click chemistry. In the study reported here, the in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. Compounds 1a, 1q, and 1r showed the more antifungal activity than the others.

Evaluation of antibiotic prescribing patterns among inpatients using World Health Organization indicators: A cross-sectional study

“…34 This result, however, was higher than the rates of 49.3% and 56.1% found in Sudan 37 and Zambia 38 studies, respectively. Furthermore, our findings are similar to those of Gondar, Ethiopia (96%), 2 Aksum, Ethiopia (97.6%), 4 Sidama, Ethiopia (95.8%), 39 Cameroon (98.36%), 23 India (98.0%), 30 and Eritrea (97%). 13 In truth, there is no difference in pharmacological efficacy between prescribing antibiotics by their brand and generic names.…”

Theoretical determination of electronic, geometric and spectroscopic properties of some 1,2,4-triazol derivatives

“…International Journal of Biology and Chemistry 16, № 2 (2023) Theoretical determination of electronic, geometric and spectroscopic properties of some 1,2,4-triazol derivatives (54) 853 861 τ HCCC (16) 855 865 τ HCCC(22), τ HCCC(50) 859 879 ν NC (14), ẟ OCN (10) 906 925 τ HCCN (10;11), ẟ HCC(13) 930 938 τ HCCN (15), τ HCCC(18), τ HCCC (17) 933 946 τ HCCN (16), τ HCCC (14), τ HCCC (25) 935 954 τ HCCN(14;10), τ HCCC(13) 951 969 τ CCCC (11), τ HCCC (17), τ HCCC (57) 976 981 τ CCCC(13), τ HCCC (25) (12) 1222 1310 ν CC (12), ν CC (11), ẟ HCC (15) 1230 1333 ν NC (20), ν CC (10) 1250 1343 ẟ HCC (20), ẟ HCC(10;26), τ HCCC (10) 1287 1358 ν CC (12), ẟ HCC (16), ẟ HCC (10) 1321 1362 ν NC (28) 1339 1365 ν NC (11) 1341 1414 ν NC(13), ẟ CNN (17), ẟ NNC (10), τ HCCN (14) 1355 1445 ẟ HCC(85) 1367 1471 ẟ HCC (16), ẟ HCC (20;17;24) 1401 1513 ν NC (11), ν CC (12), τ HCCN (29) 1439…”

“…Examples of these biological activities include antiviral [1], antibacterial [2], antifungal [3,4] (examples of antifungal drugs are fluconazole [5,6], itraconazole [7], ravuconazole [8], voriconazole [9][10][11] and posaconazole [12]), anti-tubercular [13][14][15], immunosuppressant [16], antihypertensive [17], anti-inflammatory [18,19], anticonvulsant [20,21], analgesic [22], hypoglycemic [23], antidepressant [24,25] and anticancer [26][27][28] activities. Derivatives of 1,2,4-triazoles are a significant class of antifungal medications that are frequently used to treat fungi [29]. Insecticides [30], antiasthmatics [31], antidepressants [32], insecticidal [33], and plant growth regulators [34] are all described uses for 1,2,4-triazole derivatives.…”

Triazole-Modified Peptidomimetics: An Opportunity for Drug Discovery and Development

“…Structures containing the 1,2,3-triazolyl core play an important function due to the wide therapeutic applications in antifungal therapy. For this reason, the triazole-containing drugs have been effectively developed and applied in the treatment of numerous microbial infections for years (Yu et al, 2015 ). An expanding resistance to the present antifungal treatments led to the development of novel triazole derivatives with advanced therapeutic indexes and enhanced antifungal spectrum (Wang et al, 2014 ).…”