Design, synthesis and antimycobacterial activity of cinnamide derivatives: A molecular hybridization approach

Antibacterial activity of long-chain fatty alcohols against mycobacteria

“…The search for antimycobacterial agents for both therapy and disinfection is therefore now of major research interest across the world. In this regard, research describing new antimycobcaterial agents from natural and synthetic sources is being reported with different target sites and mode of actions (Koyama et al, 2010;Kakwani et al, 2011;Lougheed et al, 2011).…”

Ethyl Cinnamate Derivatives as Promising High-Efficient Acaricides against <i>Psoroptes cuniculi</i>: Synthesis, Bioactivity and Structure–Activity Relationship

“…10) Due to their common occurrence in plants and their low toxicity, 11,12) cinnamic acid derivatives have attracted much attention of many pharmacologists. In the past decades, cinnamic acid derivatives including natural, semi-synthetic and synthetic compounds had been proven to have a variety of pharmacological activities, 13) such as anticancer, 14,15) antimicrobial, [16][17][18] antioxidative, 18) anti-inflammatory, 15,[19][20][21] anti-Mycobactrium tuberculosis, [22][23][24] antiviral, 25) anti-human immunodeficiency virus (HIV), [26][27][28] antidiabetic, 29) anticholesterolemic, 30) analgesic, 31) hepatoprotective, 32,33) immunoprotective, 34) inducing neural progenitor cell proliferation 35) and anxiolytic activity. 36) Especially, what interests us is that cinnamic acid derivatives also have significant antiparasitic activities on plasmodia, 37) Leishmania 38) and nematode.…”

Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents

“…Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis) [261], continues to be a burgeoning health quandary and a chief reason of death, particularly in the developing countries [262]. Emergence of resistance to a number of drugs is a new threat, and has paved the way for development of newer drugs [263].…”