Design, synthesis, and biological evaluation of novel 3‐(thiophen‐2‐ylthio)pyridine derivatives as potential multitarget anticancer agents

Xi, Jianjun; He, Ruoyu; Zhang, Jiankang; Cai, Zhen; Zhuang, Ran; Zhao, Yanmei; Shao, Yi; Pan, Xuwang; Shi, Tingting; Dong, Zuojun; Liu, Shourong; Kong, Limin

doi:10.1002/ardp.201900024

Cited by 5 publications

(1 citation statement)

References 27 publications

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“…Xi et al [147] designed, synthesized and evaluated a series of new 3-(thiophen-2-ylthio)pyridine derivatives to discover promising multi target antitumor agents. Distinctively compound 23 (fig.…”

Section: Miscellaneousmentioning

confidence: 99%

Pyridine Moiety: Recent Advances in Cancer Treatment

Sahu¹,

Mishra²,

Kumar³

et al. 2021

ijps

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Pyridine is an imperative pharmacophore, a privileged scaffold and an exceptional heterocyclic system in the field of drug discovery which provides many opportunities in study/explore this moiety as an anticancer agent by acting on various receptors of utmost importance. Several pyridine derivatives are reported to inhibit tubulin polymerization, androgen receptors, human carbonic anhydrase, kinase, topoisomerase enzyme and many other targets for controlling and curing global health issue of cancer. Now a days in combination with other moieties researchers are focusing for development of pyridine new entities for the treatment of cancer. This review throws light on recent biological expansions of pyridine along with their structure activity relationships/molecular docking to deliver association between various synthesized newer derivatives and receptor sites.

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Section: Miscellaneousmentioning

confidence: 99%

Pyridine Moiety: Recent Advances in Cancer Treatment

Sahu¹,

Mishra²,

Kumar³

et al. 2021

ijps

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An alignment-independent three-dimensional quantitative structure–activity relationship study on ron receptor tyrosine kinase inhibitors

Zarei

Raeppel²,

Hamzeh‐Mivehroud

2022

J. Bioinform. Comput. Biol.

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Recepteur d’Origine Nantais known as RON is a member of the receptor tyrosine kinase (RTK) superfamily which has recently gained increasing attention as cancer target for therapeutic intervention. The aim of this work was to perform an alignment-independent three-dimensional quantitative structure–activity relationship (3D QSAR) study for a series of RON inhibitors. A 3D QSAR model based on GRid-INdependent Descriptors (GRIND) methodology was generated using a set of 19 compounds with RON inhibitory activities. The generated 3D QSAR model revealed the main structural features important in the potency of RON inhibitors. The results obtained from the presented study can be used in lead optimization projects for designing of novel compounds where inhibition of RON is needed.

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A Review on the Anticancer Activity of Carbazole-based Tricyclic Compounds

Zhang,

Zhu

et al. 2024

CMC

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Cancers are a huge threat to human life and health. Every year, many people suffer and die from various cancers, and numerous resources have been used to combat cancer. Due to several disadvantages of anticancer agents, such as drug-induced side effects, drug resistance, etc., there are still wide gaps in their ability to conquer cancer. Therefore, there is an urgent need to discover and develop many novel chemotypes to suppress cancer. In this review, we mainly focus on the anticancer potency of two representative sorts of carbazole-based compounds: carboline derivatives and diazacarbazole derivatives. Diazacarbazole derivatives, which have not been fully explored yet, might bring us a new vision and a valuable opportunity for overcoming the enormous hurdle we are now facing in the cancer campaign. We also provide several synthetic approaches for constructing the critical skeletons of the carbazole-based tricyclic compounds.

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Design, synthesis, and biological evaluation of novel 3‐(thiophen‐2‐ylthio)pyridine derivatives as potential multitarget anticancer agents

Cited by 5 publications

References 27 publications

Pyridine Moiety: Recent Advances in Cancer Treatment

Pyridine Moiety: Recent Advances in Cancer Treatment

An alignment-independent three-dimensional quantitative structure–activity relationship study on ron receptor tyrosine kinase inhibitors

A Review on the Anticancer Activity of Carbazole-based Tricyclic Compounds

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