Design, Synthesis and Cytotoxic Evaluation of Novel Heterocyclic Thioglycosides

Gh, Elgemeie; Ab, Farag; Km, Amin; Om, El-Badry; Gs, Hassan

doi:10.4172/2161-0444.1000234

Cited by 8 publications

(1 citation statement)

References 29 publications

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“…A series of 2-thioxoimidazolidin-4-one and benzothiazole thioglycosides were synthesized by one-pot reaction. The cytotoxic activity of compound was evaluated against MCF-7 breast cell and it showed high-to-moderate anticancer activities (Figure 11) [11].…”

Section: Green Synthesis Of Thioxoimidazolidin and Benzothiazole Derimentioning

confidence: 99%

Green Chemistry and Synthesis of Anticancer Molecule

Perveen¹,

Al‐Taweel²

2018

Green Chemistry

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Green chemistry is a modern area of chemistry merged with chemical engineering methods. It highlighted the synthesis of molecules in a manner of using environment-friendly chemical reagents with low waste material for enhancing environmental performance which reduce the formation of hazard substances. Modern researches are trying to reduce the risk of human kind health and the environment of our world by doing magnificent work in the field of green chemistry. In the pharmaceutical field, green chemistry works very well with the formation of many drugs and it utilizes non-hazards, reproducible and environment-friendly solvents with low time and money costs by using catalyst, microwave, ultrasonic, solid phase and solvent-free synthesis. Until now, scientist has synthesized many anticancer molecules by using these modern green chemistry techniques. These compounds showed significant anticancer activities against many human cancer cell lines. In this chapter, we will cover different views and the recently published literature to summarize the role of green chemistry in the synthesis of anticancer compounds.

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Section: Green Synthesis Of Thioxoimidazolidin and Benzothiazole Derimentioning

confidence: 99%

Green Chemistry and Synthesis of Anticancer Molecule

Perveen¹,

Al‐Taweel²

2018

Green Chemistry

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Design, Synthesis, and Biological Evaluation of Thioglucoside Analogues of Gliflozin as Potent New Gliflozin Drugs

Feng,

Guo,

Tang

et al. 2023

J. Med. Chem.

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In this study, we have investigated the potential of two classes of thioglucoside analogues of gliflozins as antidiabetic drugs, one with substitutions of S-atoms in meta-positions (similar to C-glucoside SGLT2 inhibitors, TAGs A, B, and C) and the other with substitutions of S-atoms in ortho-positions (similar to Oglucoside SGLT2 inhibitors, TAGs D, E, F, and G). These TAGs were confirmed to show good stability against β-glucosidase and to have no acute toxicity to cultured cells. Most importantly, TAGs D, E, F, and G all showed high inhibitory activity against SGLT2 (IC 50 : 2.0−5.9 nM) and thus have great potential to be developed as new gliflozin drugs. Compared with the synthesis of C-glucoside gliflozins, the synthesis of TAGs is simple, efficient, and associated with low costs, high yields, and very mild reaction conditions.

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