Design, synthesis and in vitro antitubercular evaluation of novel 7-methoxy pyrrolo[1,2-a]quinoline analogues as CYP 121 inhibitors

Shivaprasad, Kondreddy; Kidwai, Saqib; Sumanth, Gopavaram; Saini, Surbhi Mahender; Reddy, K. Rajender; Chugh, Saurabh; Singh, Ramandeep; Chandrashekharappa, Sandeep

doi:10.1016/j.molstruc.2023.135439

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2024

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Cited by 8 publications

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Efficient One‐Pot Multicomponent Approach to 3‐Phenylpyrrolo[1,2‐a]Pyrazine and Novel 3‐Phenylpyrazino[1,2‐a]Indole in Aqueous Medium

Lakshmikanth,

Katiyar,

Dorai

et al. 2024

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A facile and atom‐efficient route via a new aqueous synthetic protocol for the greener and more efficient preparation of 3‐phenylpyrrolo[1,2‐a]pyrazine and 3‐phenylpyrazino[1,2‐a]indole by the one‐pot, three‐component method under mild reaction conditions is developed with substituted phenacyl bromides, aqueous ammonium hydroxide, and the corresponding 1H‐pyrrole‐2‐carbaldehyde and 1H‐indole‐2‐carbaldehyde. A reaction cascade consisting of N‐alkylation, imine formation, and annulation by condensation produces a sequence of three C−N bonds.

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