Design, Synthesis, and Pharmacological Screening of Novel Porphyrin Derivatives

Abstract

porphyrin (2f), in high yields using a new method via a capping mechanism. These dyes were used as a model to study the free radical-induced damage of biological membranes and the protective effects of these porphyrins. It was demonstrated that these dyes were effective in the inhibition of the free radical-induced oxidative haemolysis of rat blood cells. Dyes 2d and 2f which bear methoxy functionality exhibited markedly higher antihaemolysis activity than the other analogs. Molecular modeling methods using ZINDO/INDO-1, with a configuration interaction of 26, and TD-DFT using the energy functional B3LYP and the basis set DGTZVP were used to study the vertical electronic excitations of porphyrins 2a-f and it was shown that the max calculated using TD-DFT method was in excellent agreement with the experimental results, while the ZINDO method was inferior. Moreover, excellent correlation between the LUMO energy and cytotoxicity of dyes 2a-f was found.

Efficient synthesis of meso‐substituted porphyrins and molecular docking as potential new antioxidant and cytotoxicity agents

“…Interestingly, 2d exhibited a superior activity within its series analogues and this worth further study. These results were in line with our previous studies, in which porphyrin‐based aromatic amine derivatives induced a chain of biochemical alterations among which is the cell caspases activation and apoptosis induction . These alterations seem to take place primarily in specific cells (e.g., HepG2) with a disturbed intracellular redox balance.…”

Synthesis, antiviral, cytotoxicity and antitumor evaluations of A4 type of porphyrin derivatives

“…Antitumor activity [52][53][54]. RPMI-1640 medium (Sigma Co., St. Louis, USA), Foetal Bovine serum (GIBCO, UK), and the cell lines from ATCC were used.…”

Synthesis, Spectroscopic, and Biological Studies on New Zirconium(IV) Porphyrins with Axial Ligand

“…Porphyrins were reported to exhibit a variety of biological activities. This is due to the fact that natural and synthetic porphyrins have relatively low toxicity in vitro and in vivo and they possess antitumor [11, 12] and antioxidant effects [13, 14] and have a good potential for metal ions complexation. The ability for numerous chemical modifications and the large number of different mechanisms by which porphyrins affect microbial and viral pathogens place porphyrins into a group of compounds with an outstanding potential for discovery of novel agents, procedures, and materials active against pathogenic microorganisms [15].…”