Design, synthesis, anticancer and in silico assessment of 8-caffeinyl-triazolylmethoxy hybrid conjugates

Abstract

Design, synthesis, anticancer, docking and in silico assessment for 8-caffeinyl-triazolylmethoxy hybrid conjugates are explained. These compounds have remarkable activities against malanoma and breast cancer cell lines.

Design, synthesis, anticancer and in silico assessment of 8-piperazinyl caffeinyl-triazolylmethyl hybrid conjugates

“…Recently, we have reviewed and categorized the C8-modied caffeine derivatives to C8-C, C8-O, C8-S, and C8-N on the basis of the atom's type linked to C8. 16 Among C8-modied caffeine derivatives, the C8-N analogues are fabulous as they show Fig. 1 The structures of xanthine and its natural methylated derivatives.…”

“…Recently, we have reviewed and categorized the C8-modified caffeine derivatives to C8–C, C8–O, C8–S, and C8–N on the basis of the atom's type linked to C8. 16 Among C8-modified caffeine derivatives, the C8–N analogues are fabulous as they show considerable biological activities comprising anticancer, antimicrobial, antiviral and CNS stimulants. 12,16–22 The structures of some C8–N derivatives 1–9 and their corresponding biological activities are demonstrated in Fig.…”

“…16 Among C8-modified caffeine derivatives, the C8–N analogues are fabulous as they show considerable biological activities comprising anticancer, antimicrobial, antiviral and CNS stimulants. 12,16–22 The structures of some C8–N derivatives 1–9 and their corresponding biological activities are demonstrated in Fig. 3.…”

“…considerable biological activities comprising anticancer, antimicrobial, antiviral and CNS stimulants. 12,[16][17][18][19][20][21][22] The structures of some C8-N derivatives 1-9 and their corresponding biological activities are demonstrated in Fig. 3.…”

“…4) exhibiting remarkable leishmanicidal and anticancer properties. 16,22 In pursuit of our ongoing research on novel 8-caffeinyl derivatives and also inspired by the structure of compounds 10 and 11, hereby we have disclosed the synthesis, characterization, anticancer, and in silico investigation of new 8-piperazinyl caffeinyltriazolylmethyl hybrid conjugates 12.…”