2022
DOI: 10.1186/s13065-022-00852-8
|View full text |Cite
|
Sign up to set email alerts
|

Design, synthesis, anticancer evaluation and docking studies of novel 2-(1-isonicotinoyl-3-phenyl-1H-pyrazol-4-yl)-3-phenylthiazolidin-4-one derivatives as Aurora-A kinase inhibitors

Abstract: Introduction Aurora-A kinase is associated with the Aurora kinase family which has been considered a striking anticancer target for the treatment of human cancers. Objective To design, synthesize, anticancer evaluation, and docking studies of novel 2-(1-isonicotinoyl-3-phenyl-1H-pyrazol-4-yl)-3-phenylthiazolidin-4-one derivatives as Aurora-A Kinase inhibitors. Method A total of 21 Pyrazole derivatives … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

0
5
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
7
1

Relationship

2
6

Authors

Journals

citations
Cited by 8 publications
(5 citation statements)
references
References 37 publications
0
5
0
Order By: Relevance
“…These issues have been compounded by the widespread use of antibiotics and the infection caused by microorganisms resistant to drugs, 1,2 cancer is a deadly disease characterized by the uncontrolled growth of irritating cells. The medical uses of various anticancer drugs have been limited due to their non-selectivity, toxicity, side effects on healthy cells, and drug resistance [3][4][5][6] in addition to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused COVID-19, the worldwide pandemic that started by 2019, and spread quickly worldwide leading to high mortality and morbidity rates and no effective vaccines for governing the pandemic had been developed. 7,8 In this light, the development of more powerful endeavors, safer, more effective, and potent antimicrobial, anticancer and antiviral agents are urgently required to find the best treatment to fight these lethal diseases and to develop effective drugs with fewer adverse impacts.…”
Section: Introductionmentioning
confidence: 99%
“…These issues have been compounded by the widespread use of antibiotics and the infection caused by microorganisms resistant to drugs, 1,2 cancer is a deadly disease characterized by the uncontrolled growth of irritating cells. The medical uses of various anticancer drugs have been limited due to their non-selectivity, toxicity, side effects on healthy cells, and drug resistance [3][4][5][6] in addition to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused COVID-19, the worldwide pandemic that started by 2019, and spread quickly worldwide leading to high mortality and morbidity rates and no effective vaccines for governing the pandemic had been developed. 7,8 In this light, the development of more powerful endeavors, safer, more effective, and potent antimicrobial, anticancer and antiviral agents are urgently required to find the best treatment to fight these lethal diseases and to develop effective drugs with fewer adverse impacts.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, 1,3,4-oxadiazole/thiadiazole derivatives have wide-spectrum pharmacological actions. There have been some reports suggesting that a 1,3,4-oxadiazole/thiadiazole moiety may be effective as an anticancer [19][20][21], antimicrobial [22,23], antioxidant [24,25], tyrosinase inhibitor [26], cathepsin K inhibitor [27], antitubercular [28,29], anti-diabetics [30], anti-inflammatory [31][32][33], anticonvulsant [34,35], antihypertensive activities [36], etc. These heterocyclic scaffolds are the main structural backbone of a wide range of drugs.…”
Section: Introductionmentioning
confidence: 99%
“…Many different types of therapeutic approaches are being applied for the treatment of cancer. Several anticancer drugs are available around the world but most drugs are associated with large numbers of serious side effects, toxicity, and drug resistance [ 3 , 4 ]. Thus, it is crucial to develop novel anticancer molecules with great potential and fewer side effects.…”
Section: Introductionmentioning
confidence: 99%