Design, synthesis of novel azo derivatives of benzimidazole as potent antibacterial and anti tubercular agents

Unexpected Ring Opening During the Imination of Camphor‐Type Bicyclic Ketones

“…To search for other ketones capable of reacting with osubstituted anilines, we carried out similar transformations with the bicyclic natural monoterpenoid, (À )-fenchone (8), and a commercially available norcamphor (12). Thus, new diastereoisomeric mixtures of heterocyclic compounds (9 a, b; 10 a, b; 11 a, b) were synthesised (Scheme 4).…”

“…Benzimidazoles, benzoxazoles, and benzothiazoles are important bioactive heterocyclic scaffolds and exhibit a broad spectrum of biological and pharmacological properties [2–7] including anti‐bacterial, [8–11] antiviral, [12–16] anti‐fungal, [17–19] anti‐inflammatory, [20–22] anti‐cancer [23–25] . There is considerable interest in the synthesis and biological evaluation of novel benzimidazole derivatives, including chiral ones, due to their wide range of biological activities [26–28] .…”

“…A combination of two biologically active structures in one molecule can increase the efficiency of the pharmacological action of the constituents or give new properties to the resulting hybrid drug. [1] Benzimidazoles, benzoxazoles, and benzothiazoles are important bioactive heterocyclic scaffolds and exhibit a broad spectrum of biological and pharmacological properties [2][3][4][5][6][7] including anti-bacterial, [8][9][10][11] antiviral, [12][13][14][15][16] anti-fungal, [17][18][19] antiinflammatory, [20][21][22] anti-cancer. [23][24][25] There is considerable interest in the synthesis and biological evaluation of novel benzimidazole derivatives, including chiral ones, due to their wide range of biological activities.…”

Suzuki-Miyaura Çapraz Eşleşme Reaksiyonunda Katalizör Olarak Heterosiklik Bileşiklerin Uygulanması

“…Compounds containing benzimidazole nucleus demonstrate a wide variety of biological activity properties such as anticancer, antitubercular antimicrobial, antifungal, antioxidant, antidiabetic and etc [1][2][3][4][5][6][7][8][9][10][11][12][13]. On the other hand, heterocyclic benzimidazole derivatives have different application area and can be used as catalysts [14][15][16] and sensors [17,18].…”

Design, synthesis, characterization, and in vitro cytotoxic activity evaluation of 1,2‐disubstituted benzimidazole compounds

“…[1] Furthermore, compounds containing benzimidazole nucleus have many other biological activities such as antimicrobial, anthelmintic, analgesic, antiulcer, antiviral, anticancer, antioxidant, antihypertensive, antiinflammatory, antifungal, and diuretic activities. [2][3][4][5][6][7][8][9][10][11][12][13][14][15] There are a lot of commercial drugs containing benzimidazole core, for example, bendamustine is a chemotherapy drug used to treat chronic lymphocytic leukemia, multiple myeloma, and non-Hodgkin's lymphoma. Bezitramide is an opioid analgesic.…”