Designed Blending for Near Infrared Calibration

Scheibelhofer, Otto; Grabner, Bianca; Bondi, Robert W.; Igne, Benoît; Sacher, Stephan; Khinast, Johannes G.

doi:10.1002/jps.24488

Cited by 8 publications

(1 citation statement)

References 41 publications

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“…A change in physical properties alters the observed absorption spectrum. 15,16 A change in a chemical composition modifies the physical properties of the sample (e.g., mixing various powder components with various particle sizes) and, ultimately, the scattering behavior. 9 Efforts have been made to separate the absorptive and scattering parts of spectra.…”

Section: Absorption and Scatteringmentioning

confidence: 99%

Spatially Resolved Spectral Powder Analysis: Experiments and Modeling

et al. 2018

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Understanding the behavior of light in granular media is necessary for determining the sample size, shape, and weight when probing using fiber optic setups. This is required for a correct estimate of the active pharmaceutical ingredient content in a pharmaceutical blend via near-infrared spectroscopy. Several strategies to describe the behavior of light in granular and turbid media exist. A common approach is the Monte-Carlo simulation of individual photons and their description using mean free path lengths for scattering and absorption. In this work, we chose a complementary method by approximating these parameters via real physical counterparts, i.e., the particle size, shape, and density and the resulting chord lengths. Additionally, the wavelength dependence of refractive indices is incorporated. The obtained results were compared with those obtained in an experimental setup that included the SAM-Spec Felin probe head by Indatech for detecting spatially resolved spectra of samples. Our method facilitates the interpretation of the acquired experimental results by contrasting the optical response, the physical particle attributes, and the simulation results.

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Section: Absorption and Scatteringmentioning

confidence: 99%