Designing 3D-nanosubstrates mimicking biological cell growth: pitfalls of using 2D substrates in the evaluation of anticancer efficiency

Abstract

Designing nano-substrates (NS) that support three-dimensional (3D) cell growth using physico-chemical interventions mimicking cellular microenvironment is highly challenging. Here we report NS that assist 3D cell development (3D NS) using...

Synthesis and Biological Evaluation of Novel Fusidic Acid Derivatives as Two-in-One Agent with Potent Antibacterial and Anti-Inflammatory Activity

“…A bacterial infection caused by S. aureus can cause a serious threat to human public health. This kind of bacteria is difficult to eradicate completely, resulting in a high infection probability with a severe mortality rate [ 2 ]. Being an opportunistic pathogen, it is capable of causing various skin and soft tissue infections, such as impetigo, cellulitis, boils, and folliculitis [ 3 ].…”

Chemical tunability of advanced materials used in the fabrication of micro/nanobots

“…Work by Khandare et al on ''static'' advanced materials demonstrated diverse bio-functionality generated by altering the chemistry of iron oxide nanoparticles, carbon nanotubes and graphene nanosheets for applications in drug delivery and targeted enrichment of circulating tumor cells (CTCs). [85][86][87][88][89] Thus, demonstrating that libraries of advanced materials can be investigated for varied applications via simple surface chemical modifications. A similar extrapolation can be drawn to MNBs, wherein a library of chemical compositions with self-propulsion capabilities can be achieved via the chemical surface modification of ''static'' NPs transforming them into ''active micro/nano motor'' entities.…”