In this study, we examined a tank container for foodstuff that is generally used for the transport of foodstuffs. With the aid of the “ANSYS R17.0” program code, a numerical model of the tank container for foodstuffs was realized. Further, to validate the considered model, the tank container considered was submitted to the most important ISO tests concerning both its support frame and the tank. The results obtained from the FEM analysis, in terms of displacement for each test, were compared with those provided by the manufacturer and related to the tank container considered, evaluating the difference between the numerical results with the experimental ones. This allowed us to validate the model examined. Furthermore, the results obtained from each test, in terms of stress, have made it possible to locate the areas with the highest equivalent stress and quantify the maximum value, comparing it with the allowable stress. In this way, a better understanding of the structure was achieved, and it was detected that the most stressed area is that of the connections between the container and the frame. Furthermore, modal analysis was carried out, in which the natural frequencies relating to the most dangerous modes of vibrations were found, that is, with the lowest frequency values. Finally, changes for the considered tank container were examined, and it was found that, by changing parameters, such as the thickness of the plate and skirt, and subsequently acting on the arrangement of the corner supports, the highest value of the stresses generated by the loads related to the ISO tests, it is significantly lowered, resulting in a better distributed stiffening of the structure and a reduction, although minimal, of weight. It is evident that this modeling and validation method, suitably integrated by further calculation modules, can be used in an iterative optimization process.