Designing a multitarget In(iii) compound to overcome the resistance of lung cancer cells to cisplatin

Abstract

Designing novel anticancer non-platinum metal agents is fully challenging. Herein, a series of little-known indium (In) 2-acetylpyridine thiosemicarbazone compounds as potential anticancer agents were designed, synthesized, and characterized. The hydrogen...

Developing an Anticancer Platinum(II) Compound Based on the Uniqueness of Human Serum Albumin

“…Thiosemicarbazone compounds are not only promising anticancer agents but can also be easily coordinated with metals because they contain sulfur atoms and nitrogen atoms. − To obtain a Pt­(II) thiosemicarbazone compound with remarkable cytotoxicity and low toxicity, we designed and synthesized a series of Pt­(II) thiosemicarbazone compounds. The crystal structures of four Pt­(II) compounds (C1–C4) were identified by X-ray crystallography (Figure ).…”