Designing, characterization, and thermal behavior of triazine-based dendrimers

Abstract

Different generations of dendritic architecture with piperazine in core moiety and hydroxyl groups on the periphery were designed by divergent method. 1,4-biz(4,6-trichloro-1,3,5-triazin-2-yl)piperazine was synthesized as a core for dendrimer synthesis. Dendrimer was then grown to G3 from core compound using diethanolamine and cyanuric chloride as branching units. Dendrimer generations were characterized by infrared (IR) spectroscopy [Fourier transform IR (FTIR)], 1 H-nuclear magnetic resonance (NMR), 13 C-NMR, electrospray ionization-mass spectrometry (ESI-MS), and elemental analysis. The thermal behavior of both full-and half-generation dendrimers was investigated by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The TGA study revealed that dendrimer generations had a moderate thermal stability. Chlorine-terminated half-generation dendrimers were thermally more stable than hydroxyl-terminated fullgeneration dendrimers. The DSC technique was employed to determine the glass transition temperatures (Tg) of dendrimer generations. It was observed that the glass transition temperatures of synthesized dendrimer generations were of low value, which is similar to the values reported for the polyamidoamine (PAMAM) dendrimer of the same generation. It was also observed that, with the increase in the molecular weight or generation number of dendrimer, the glass transition temperature was also increased.

Modification of halloysite nanotubes by hydroxyl terminated triazine‐based dendritic polymer for efficient adsorptive removal of Cd (II) from aqueous media

“…[ 52 ] Concerning HNT‐G1, the 3400, 2960, 2853, 1645, and 1060 cm −1 absorption bands could be respectively assigned to the stretching vibrations of O–H, −CH, C=N, and C–O chemical bonds. [ 47 ] Regarding FT‐IR spectrum in HNT‐G1.5, the 2910, 1633, 1039, and 795 cm −1 absorption peaks may be may be ascribed to the stretching vibrations of C–H, C=N, C–O, and C–Cl chemical bonds, respectively. As for the HNT‐G2, the comparison of spectra of core, HNT‐G1, and HNT‐G1.5 and considering the recorded peaks, conclusion can be made that the OH, C=N, CH, and C–O bonds exist.…”

“…In the end, in order to synthesize the G2 dendrimer, a mixture of G1.5 (0.8 g) and bis(2‐hydroxyethyl)amine (0.16 mmol) was prepared and left to reflux for 2 h. When it was cold, we spread it and washed it using acetone several times, and this way, G2 was obtained. [ 47 ]…”

“…[50] Also, the 3429, 2937, 795, and 687 cm À1 absorption bands could be due to -OH water stretching, ÀCH stretching in methylene groups (CH 2 ), C-Cl stretching, and the presence of Al-O-Si groups. [8,47,51] Another peak at 1630 cm À1 resulted from the stretching of imine group (C=N), denoting the presence of triazine ring. [52] Concerning HNT-G1, the 3400, 2960, 2853, 1645, and 1060 cm À1 absorption bands could be respectively assigned to the stretching vibrations of O-H, ÀCH, C=N, and C-O chemical bonds.…”

Triazine Dendrimers an Excellent Drug Carrier for Improving the Solubility of Glyburide

“…The generation 1.0 (HG 1.0) dendrimer that had been earlier synthesised underwent a reaction in the presence of cyanuric chloride, forming the generation 1.5 (HG 1.5) dendrimer. The process was then continued until dendrimers of generation three (HG3.0) were synthesised [25][26][27][28][29][30][31]. Yield: 83.52% 2.4 Phase Solubility mmol) of dendrimer generations in buffers of 4.0, 6.0, and 9.2 pH to conduct a solubility investigation following the methodology established by Higuchi and Connors [32].…”

Triazine Dendrimers: An Excellent Drug Carrier for Improving the Solubility of Glyburide an Antidiabetic Agent

“…G1 dendrimer was again utilized and reacted with cyanuric chloride which gives dendrimer generation 1.5 (G1.5). Then all the steps were carried out repeatedly till dendrimer generation 3 (G3) was synthesized [25][26][27]31].…”