Designing Dendrimer and Miktoarm Polymer Based  Multi-Tasking Nanocarriers for Efficient Medical Therapy

Sharma, Anjali; Kakkar, Ashok

doi:10.3390/molecules200916987

Cited by 57 publications

(42 citation statements)

References 169 publications

(188 reference statements)

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“…PSM was used for the introduce chelating units in the core, inside and on the surface of dendrimers . However, selective modification of the dendrimer surface for various functions is very difficult .…”

Section: Preparation Of Chelating Dendrimersmentioning

confidence: 99%

“…PSM was used for the introduce chelating units in the core, inside and on the surface of dendrimers. [209] However, selective modification of the dendrimer surface for various functions is very difficult. [210] As a typical example, we note a surface modification of phosphorus-containing dendrimers to obtain (+)-cinchonine fragments.…”

Section: Post-synthetic Modification Of Dendrimersmentioning

confidence: 99%

See 1 more Smart Citation

Synthetic Methodologies for Chelating Polymer Ligands: Recent Advances and Future Development

Джардималиева

Uflyand

2018

ChemistrySelect

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This review summarizes recent progress in synthetic methodologies of chelating polymer ligands such as linear, branched, cross‐linked, grafted polymers, polymer films, liquid crystal polymers, dendrimers, star‐shaped and hyperbranched polymers. The features of methods for producing chelating polymer ligands are considered in detail: free‐radical (co)polymerization, living/controlled radical, metathesis, grafted, chemical oxidized, microwave‐assisted and asymmetric polymerization, electropolymerization, cyclopolymerization, polycondensation, post‐polymerization modification, click chemistry methods and “green” synthesis. The main directions of the development of synthetic chemistry of chelating polymeric ligands are analyzed. The bibliography includes works published in the last five years.

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Section: Preparation Of Chelating Dendrimersmentioning

confidence: 99%

Section: Post-synthetic Modification Of Dendrimersmentioning

confidence: 99%

Synthetic Methodologies for Chelating Polymer Ligands: Recent Advances and Future Development

Джардималиева

Uflyand

2018

ChemistrySelect

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“…Due to their asymmetry, miktoarm variants are categorized in the form: A x B y C z , where A, B, and C are examples of polymeric chains, and the subscript denotes their number ( Figure 1 ). The branching architectures of miktoarm polymers have contributed distinct properties to their aqueous self-assemblies, compared to those from their linear diblock copolymer counterparts, including very low CMCs, smaller sizes, and most importantly the ability to encapsulate large amounts of drug molecules [ 20 , 21 , 22 , 23 , 24 , 25 ]. In addition, the tunability offered by having multiple branching segments has led to the synthesis of a variety of micelle structures that incorporate polymeric arms with stimulus-responsive units and biological targeting moieties.…”

Section: Introductionmentioning

confidence: 99%

Miktoarm Star Polymers: Branched Architectures in Drug Delivery

Lotocki

Kakkar

2020

Pharmaceutics

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Delivering active pharmaceutical agents to disease sites using soft polymeric nanoparticles continues to be a topical area of research. It is becoming increasingly evident that the composition of amphiphilic macromolecules plays a significant role in developing efficient nanoformulations. Branched architectures with asymmetric polymeric arms emanating from a central core junction have provided a pivotal venue to tailor their key parameters. The build-up of miktoarm stars offers vast polymer arm tunability, aiding in the development of macromolecules with adjustable properties, and allows facile inclusion of endogenous stimulus-responsive entities. Miktoarm star-based micelles have been demonstrated to exhibit denser coronae, very low critical micelle concentrations, high drug loading contents, and sustained drug release profiles. With significant advances in chemical methodologies, synthetic articulation of miktoarm polymer architecture, and determination of their structure-property relationships, are now becoming streamlined. This is helping advance their implementation into formulating efficient therapeutic interventions. This review brings into focus the important discoveries in the syntheses of miktoarm stars of varied compositions, their aqueous self-assembly, and contributions their formulations are making in advancing the field of drug delivery.

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“…Dendrimers provide a three dimensional architecture with void cavities in the internal part and many functional branches grow radially from the core. These properties make it possible to either encapsulate a drug within interior cavity or to the highly symmetric branched outer layer through either covalent bonding or noncovalent complexation (15)(16)(17). Among all dendrimers, PAMAM dendrimers are widely used as drug or gene carriers (18).…”

Section: Introductionmentioning

confidence: 99%

PAMAM-dendrimer Enhanced Antibacterial Effect of Vancomycin Hydrochloride Against Gram-Negative Bacteria

et al. 2018

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Purpose: The antibacterial activity of some antibiotics is specific to either Gram-positive or Gram-negative bacteria. There are different mechanisms behind such insensitivities like inability of antibiotics to permeate through some bacterial membranes, as is the case for vancomycin in Gram-negative bacteria. The present investigation tries to overcome this problem by dendrimers, in order to make Gram-negative bacteria responsive to vancomycin. Methods: The effects of generations 3 (G3) and 5 (G5) polyamidoamine amine-terminated dendrimers (NH2-PAMAM), on the antibacterial activity of vancomycin, were evaluated. Vancomycin-PAMAM dendrimers complexes were prepared and their antibacterial activities were evaluated by determination of their “minimum inhibitory concentration (MIC)”, “minimum bactericidal concentration” and “fractional inhibitory concentration index” values against two Gram-positive and four Gram-negative bacteria, using broth micro-dilution method. The complexation of vancomycin and dendrimers was also assessed by in vitro release studies across dialysis tubing using a developed HPLC method. Results: Results showed that vancomycin solution was effective against Gram-positive bacteria, but, was not effective in Gram-negative ones. Vancomycin-PAMAM dendrimers exhibited significant antibacterial efficacy against Gram-negative bacteria resulting in a decline of vancomycin MIC values by about 2, 2, 4 and 64 times in E. coli, K. pneumonia, S. typhimurium and P. aeruginosa, respectively. Results also showed that enhanced effect by G5 is more than G3. Dendrimers did not affect antibacterial activity of vancomycin in Gram-positive bacteria, as no permeation problem exists here. Conclusions: The present study revealed that both G3 and G5 cationic PAMAM dendrimers are able to make Gram-negative bacteria sensitive to vancomycin, resulting in decline of MIC values up to 64 times, possibly by increasing its permeation through bacterial membrane. These results look promising for broadening the antibacterial spectrum of vancomycin and such a strategy might be used for increasing the overall life of antibiotics.

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Designing Dendrimer and Miktoarm Polymer Based Multi-Tasking Nanocarriers for Efficient Medical Therapy

Cited by 57 publications

References 169 publications

Synthetic Methodologies for Chelating Polymer Ligands: Recent Advances and Future Development

Synthetic Methodologies for Chelating Polymer Ligands: Recent Advances and Future Development

Miktoarm Star Polymers: Branched Architectures in Drug Delivery

PAMAM-dendrimer Enhanced Antibacterial Effect of Vancomycin Hydrochloride Against Gram-Negative Bacteria

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