In face of the technological changes derived from Industry 4.0, an initial, gradual and complex process of Technology Transfer (TT) is taking place that strongly relies on the integration between university, industry, and government. In this context, in order to make the Industry 4.0 approach a reality, several requirements need to be met. One of them is the need to qualify people to work in industries. This study aimed to explore the possible changes and perspectives of human work in Industry 4.0. A systematic literature review was carried out following a structured script. 50 were chosen for content analysis, following criteria for qualification and selection of studies. As a result, a number of changes in human skills and tasks, as well as job prospects, were found, standing out the greater flexibility of people, ability for decision-making, among others.