Designing Liver Resections and Pushing the Envelope with Resections for Hepatic Colorectal Metastases

Guye, Mary L.; Schoellhammer, Hans F.; Chiu, Louisa W.; Kim, Joseph; Lai, Lily; Singh, Gagandeep

doi:10.1007/s13193-013-0256-5

Cited by 4 publications

(4 citation statements)

References 72 publications

(96 reference statements)

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“…1) [10,11]. However, all of these criteria have been challenged over the past decade as they were derived from antiquated studies and the definition of resectability has been modified [7].…”

Section: Historical Perspectivementioning

confidence: 99%

“…Fong's clinical risk score is the most widely utilized system today. However, none of these scoring systems are relied upon for absolute determination of resectability due to inherent inaccuracies and as such, they function solely as a guideline [7]. Preoperative radiologic imaging, therefore, plays the primary role in staging of colorectal cancer, specifically with regard to the feasibility of hepatic resection.…”

Section: Current Criteriamentioning

confidence: 99%

“…Marginnegative surgical resection, also referred to as R0 resection, is known to represent the only curative therapy and, as a result, has been the standard of care for colorectal hepatic metastases [6]. Resection has resulted in 5-year survival rates reported between 30-60% [2,7]. The significant improvement in 5-year survival rates for patients with colorectal hepatic metastases over the past two decades is in part due to a paradigm shift in the philosophy of treatment, in addition to improved chemotherapeutic agents [8].…”

mentioning

confidence: 99%

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Role of imaging for patients with colorectal hepatic metastases: what the radiologist needs to know

et al. 2015

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Surgical resection of colorectal metastatic disease has increased as surgeons have adopted a more aggressive ideology. Current exclusion criteria are patients for whom a negative resection margin is not feasible or a future liver remnant (FLR) of greater than 20% is not achievable. The goal of preoperative imaging is to identify the number and distribution of liver metastases, in addition to establishing their relation to relevant intrahepatic structures. FLR can be calculated utilizing cross-sectional imaging to select out patients at risk for hepatic dysfunction after resection. MRI, specifically with gadoxetic acid contrast, is currently the preferred modality for assessment of hepatic involvement for patients with newly diagnosed colorectal cancer, to include those who have undergone neoadjuvant chemotherapy. Employment of liver-directed therapies has recently expanded and they may provide an alternative to hepatectomy in order to obtain locoregional control in poor surgical candidates or convert patients with initially unresectable disease into surgical candidates.

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Section: Historical Perspectivementioning

confidence: 99%

Section: Current Criteriamentioning

confidence: 99%

mentioning

confidence: 99%

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Role of imaging for patients with colorectal hepatic metastases: what the radiologist needs to know

et al. 2015

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“…Colorectal cancer (CRC) is the third most common diagnosis and second deadliest malignancy worldwide. 1 Although multidisciplinary cooperative therapies, including radiotherapy, neo-adjuvant chemotherapy, and surgery, were helpful to improve the patients’ survival, 2 the prognosis of CRC patients remains poor. 3 Therefore, it is urgent to seek novel biomarkers to develop individualized treatment for each CRC patient.…”

Section: Introductionmentioning

confidence: 99%

CircFADS2: A potential prognostic biomarker of colorectal cancer

Xiao

Tong

Yuan

et al. 2020

Exp Biol Med (Maywood)

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Recent studies have displayed that circular RNA plays a key regulatory role in tumorigenesis and development. However, evidence supporting the critical role of circular RNA in the prognosis of colorectal cancer (CRC) is still limited. This study was designed to screen and identify novel circular RNA biomarkers in CRC. The microarray analysis of circular RNA expression profile was performed in three matched CRC and normal tissues. Compared with normal mucosa, a total of 208 differentially expressed circular RNAs were found in CRC, of which 95 were upregulated and 113 were downregulated. Then, the top 10 circular RNAs with the most significant differential expression were selected for verification by quantitative polymerase chain reaction (qPCR) in the above samples. The results of qPCR basically coincided with the findings of microarray analysis. The hsa_circ_022382 expression was the most significant upregulation in CRC among the 10 circular RNAs validated by qPCR. Because hsa_circ_022382 is derived from the human FADS2 gene, we named it circFADS2. Next, the increased expression of circFADS2 was further confirmed by qPCR, and its correlation with clinicopathologic parameters was analyzed in 200 CRC tissues. Herein, the expression of circFADS2 was shown to increase in 187 cases and decrease in 13 cases of CRC, and the elevated circFADS2 expression was closely related to the size, differentiation, infiltration depth, lymphatic and distant metastasis, and tumor/node/metastasis (TNM) stage of CRC. The survival analyses by Kaplan–Meier method demonstrated that patients with higher circFADS2 expression levels had shorter overall survival time and vice versa. Cox regression and area under ROC curve analyses revealed that the circFADS2 expression may be a promised biomarker for prognosis of CRC patients and had better prediction value when combined with TNM stage. In conclusion, our study identifies circFADS2 as an oncogenic biomarker and a potential prognostic factor in CRC. Impact statement Colorectal cancer (CRC) is the third most common malignancy worldwide with the second highest mortality rate. Although multidisciplinary cooperative therapies are helpful for improving the survival of CRC patients, the prognosis remains poor. Therefore, it is imperative to seek new biomarkers for the development of individualized treatment for each CRC patient. Circular RNA, an endogenous transcript with specific covalent closed loop, exhibits higher stability, conservation and expression abundance than the corresponding linear component and thus may be utilized as a promised biomarker. Although the majority of studies have focused on circular RNA expression profiling in various types of cancers, evidence supporting their critical role in the diagnosis and prognosis of CRC is limited. This study aimed to screen and identify novel circular RNA biomarkers of CRC by chip analysis and qPCR verification, and to highlight their potential as targets for CRC prognosis, and therapy.

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Computertomographie und/oder Magnetresonanztomographie der Leber

Pöhler

Ringe

2019

Radiologe

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Designing Liver Resections and Pushing the Envelope with Resections for Hepatic Colorectal Metastases

Cited by 4 publications

References 72 publications

Role of imaging for patients with colorectal hepatic metastases: what the radiologist needs to know

Role of imaging for patients with colorectal hepatic metastases: what the radiologist needs to know

CircFADS2: A potential prognostic biomarker of colorectal cancer

Computertomographie und/oder Magnetresonanztomographie der Leber

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