2021
DOI: 10.1016/j.ccr.2021.214082
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Designing magnetic nanoparticles for in vivo applications and understanding their fate inside human body

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Cited by 40 publications
(25 citation statements)
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“…Under the perspective to ensure safety future in vivo applications, it is still mandatory to assess the MNPs’ time-dependent biodistribution and clearance [ 50 , 51 ]. In this way, our results for Ci-MnFe 2 O 4 MNPs distribution and clearance made it possible to observe a predominant retention profile in the liver and spleen.…”
Section: Discussionmentioning
confidence: 99%
“…Under the perspective to ensure safety future in vivo applications, it is still mandatory to assess the MNPs’ time-dependent biodistribution and clearance [ 50 , 51 ]. In this way, our results for Ci-MnFe 2 O 4 MNPs distribution and clearance made it possible to observe a predominant retention profile in the liver and spleen.…”
Section: Discussionmentioning
confidence: 99%
“…By carefully selecting and tuning the synthetic procedure and adjusting its parameters, MNPs can be obtained practically with full control over their physicochemical properties (size, shape, composition, monodispersity, etc .). 132,133 This in turn can translate into improved magnetic properties, which are critical for magnetogenetic actuation, as described in section 2.2 of this review. These advances in the preparation of magnetic actuators with tailored properties provide exciting opportunities for the field, as is for instance the case of using a mixture of MNPs with different sizes, shapes and compositions, each one susceptible for activation by a different combination of AMF amplitude and frequency.…”
Section: Discussionmentioning
confidence: 98%
“…SPIONs have high saturation magnetisation and magnetic susceptibility, are chemically stable, biocompatible, biodegradable and non-toxic in nature. Iron oxide nanoparticles can be synthesised with ease and many different approaches have been reported, which include hydrothermal, solvothermal, sol-gel methods, co-precipitation, microwave-assisted, chemical vapour deposition, electrochemical, laser pyrolysis techniques and biosynthesis [ 16 , 17 ]. For biomedical applications, magnetic nanoparticles of iron oxide with the crystal structure of maghemite and magnetite are the most explored, and the temperature and pressure of the reaction conditions are mainly used to control the size and morphology of these MNPs.…”
Section: Magnetic Nanoparticles and Bone Tissue Engineeringmentioning
confidence: 99%