Magnetogenetics: remote activation of cellular functions triggered by magnetic switches

Fernández, S. Del Sol; Martínez-Vicente, Pablo; Gomollón-Zueco, Pilar; Castro-Hinojosa, Christian; Gutiérrez, Lucía; Fratila, Raluca M.; Moros, María

doi:10.1039/d1nr06303k

Cited by 36 publications

(34 citation statements)

References 142 publications

(301 reference statements)

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“…adaptable hydrogel), the Gr/Si interface may be not adaptable for cells toward adipogenesis and chondrogenesis [ 83 ]. Although magnetic field-mediated nanoplate and nano-assembly by tuning the binding of integrin to RGDs could promote focal adhesion, mechanotransduction, and differentiation of stem cells in a reversible manner [ 84 , 85 ], the off-target effects and low reproducibility of “nano-magnetic particles” remain challenging [ 86 ]. In this regard, the Gr/Si system owned a simple and homogeneous surface, capable of large-scale production of reproducible photovoltaic substrates for biomedical applications.…”

Section: Resultsmentioning

confidence: 99%

Dynamic photoelectrical regulation of ECM protein and cellular behaviors

Wang

Cai²,

Yao³

et al. 2023

Bioactive Materials

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Section: Resultsmentioning

confidence: 99%

Dynamic photoelectrical regulation of ECM protein and cellular behaviors

Wang

Cai²,

Yao³

et al. 2023

Bioactive Materials

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“… 1 In recent years, new biomedical approaches using these particles keep arising. Some examples include their use in wound repair, 2 drug release from different carriers, 3 tissue cryopreservation and rewarming, 4 or magnetogenetics, 5 among others.…”

Section: Introductionmentioning

confidence: 99%

Iron Speciation in Animal Tissues Using AC Magnetic Susceptibility Measurements: Quantification of Magnetic Nanoparticles, Ferritin, and Other Iron-Containing Species

Fernández‐Afonso

Asín

Beola

et al. 2022

ACS Appl. Bio Mater.

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The simultaneous detection and quantification of several iron-containing species in biological matrices is a challenging issue. Especially in the frame of studies using magnetic nanoparticles for biomedical applications, no gold-standard technique has been described yet and combinations of different techniques are generally used. In this work, AC magnetic susceptibility measurements are used to analyze different organs from an animal model that received a single intratumor administration of magnetic nanoparticles. The protocol used for the quantification of iron associated with the magnetic nanoparticles is carefully described, including the description of the preparation of several calibration standard samples of nanoparticle suspensions with different degrees of dipolar interactions. The details for the quantitative analysis of other endogenous iron-containing species such as ferritin or hemoglobin are also described. Among the advantages of this technique are that tissue sample preparation is minimal and that large amounts of tissue can be characterized each time (up to hundreds of milligrams). In addition, the very high specificity of the magnetic measurements allows for tracking of the nanoparticle transformations. Furthermore, the high sensitivity of the instrumentation results in very low limits of detection for some of the iron-containing species. Therefore, the presented technique is an extremely valuable tool to track iron oxide magnetic nanoparticles in samples of biological origin.

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“…It is worth mentioning that the MNP response to external MFs is dependent on many different parameters, including intrinsic MNP properties, such as size, shape, magnetic properties, and external properties of MFs, and media, such as the field amplitude, frequency, geometry, temperature, and media viscosity. Each of them is of great importance for magneto-mechanical approach implementation and has a significant impact on the observed biological effects [ 11 ]. Moreover, such a variety of parameters makes it mostly impossible to take into account all of them in one theoretical model.…”

Section: Introductionmentioning

confidence: 99%

Magneto-Mechanical Approach in Biomedicine: Benefits, Challenges, and Future Perspectives

Никитин

Ivanova

Semkina

et al. 2022

IJMS

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The magneto-mechanical approach is a powerful technique used in many different applications in biomedicine, including remote control enzyme activity, cell receptors, cancer-selective treatments, mechanically-activated drug releases, etc. This approach is based on the use of a combination of magnetic nanoparticles and external magnetic fields that have led to the movement of such nanoparticles with torques and forces (enough to change the conformation of biomolecules or even break weak chemical bonds). However, despite many theoretical and experimental works on this topic, it is difficult to predict the magneto-mechanical effects in each particular case, while the important results are scattered and often cannot be translated to other experiments. The main reason is that the magneto-mechanical effect is extremely sensitive to changes in any parameter of magnetic nanoparticles and the environment and changes in the parameters of the applied magnetic field. Thus, in this review, we (1) summarize and propose a simplified theoretical explanation of the main factors affecting the efficiency of the magneto-mechanical approach; (2) discuss the nature of the MNP-mediated mechanical forces and their order of magnitude; (3) show some of the main applications of the magneto-mechanical approach in the control over the properties of biological systems.

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Magnetogenetics: remote activation of cellular functions triggered by magnetic switches

Abstract: During the last decade, the possibility to remotely control intracellular pathways using physical tools has opened the way to novel and exciting applications, both in basic research and clinical applications....

Cited by 36 publications

References 142 publications

Dynamic photoelectrical regulation of ECM protein and cellular behaviors

Dynamic photoelectrical regulation of ECM protein and cellular behaviors

Iron Speciation in Animal Tissues Using AC Magnetic Susceptibility Measurements: Quantification of Magnetic Nanoparticles, Ferritin, and Other Iron-Containing Species

Magneto-Mechanical Approach in Biomedicine: Benefits, Challenges, and Future Perspectives

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