Designing Multiagent Dental Materials for Enhanced Resistance to Biofilm Damage at the Bonded Interface

Abstract

The oral environment is considered to be an asperous environment for restored tooth structure. Recurrent dental caries is a common cause of failure of tooth-colored restorations. Bacterial acids, microleakage, and cyclic stresses can lead to deterioration of the polymeric resin-tooth bonded interface. Research on the incorporation of cutting-edge anticaries agents for the design of new, long-lasting, bioactive resin-based dental materials is demanding and provoking work. Released antibacterial agents such as silver nanoparticles (NAg), nonreleased antibacterial macromolecules (DMAHDM, dimethylaminohexadecyl methacrylate), and released acid neutralizer amorphous calcium phosphate nanoparticles (NACP) have shown potential as individual and dual anticaries approaches. In this study, these agents were synthesized, and a prospective combination was incorporated into all the dental materials required to perform a composite restoration: dental primer, adhesive, and composite. We focused on combining different dental materials loaded with multiagents to improve the durability of the complex dental bonding interface. A combined effect of bacterial acid attack and fatigue on the bonding interface simulated the harsh oral environment. Human saliva-derived oral biofilm was grown on each sample prior to the cyclic loading. The oral biofilm viability during the fatigue performance was monitored by the live-dead assay. Damage of the samples that developed during the test was quantified from the fatigue life distributions. Results indicate that the resultant multiagent dental composite materials were able to reduce the acidic impact of the oral biofilm, thereby improving the strength and resistance to fatigue failure of the dentin-resin bonded interface. In summary, this study shows that dental restorative materials containing multiple therapeutic agents of different chemical characteristics can be beneficial toward improving resistance to mechanical and acidic challenges in oral environments.

Bioactive Dental Composites and Bonding Agents Having Remineralizing and Antibacterial Characteristics

“…With the purpose of enhancing the bonded interface durability, a study investigated the effect of NACP and an antibacterial monomer on dentin bonding after biofilm degradation [37]. The bonding agent and composite contained NACP as well as other antibacterial agents.…”

“…The results showed that biofilm challenge significantly reduced the flexural strength and fatigue resistance of the resin-dentin interface of the control group. However, the antibacterial and remineralizing materials were able to reduce the cariogenic impact of the biofilm, thereby improving the mechanical strength and fatigue resistance of the dentin-resin bonded interface [37]. …”

Investigation of Bacterial Adhesion on Nanoparticle Filler-Reinforced Dental Composites after Different One-Step Finishing Timing Using a Constant-Depth Film Fermenter

“…Saliva was pooled in equal volumes of each sample, and 30% glycerol will be added [18]. All samples were stored at -80°C until needed.…”

SeNPs/PLGA Inhibits Biofilm Formation by Cultivable Oral Bacteria Isolated from Caries-Active Children

“…Different nanoparticles such as silver, copper-oxide, titanium-oxide, zincoxide, silicon-dioxide, etc. have been applied for controlling oral biofilm formation (Mohamed, 2012;Melo et al, 2016). For the best of our knowledge, there is no available scientific study on application of selenium nanoparticles to control of biofilm formation on dental field.…”