Designing of Novel Topical in Situ Polymeric Film-Forming Solution Spray Formulation of Antifungal Agent: In Vitro Activity and in Vivo Characterization

Abdullah, Nabil; Patil, Amit B

doi:10.22159/ijap.2022v14i1.43581

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…Herbal extracts have been widely accepted as potential medicines with less side effects as compared to synthetic drug molecules. In recent years, the focus has been directed towards the development of drug delivery system using biologically active compounds derived from natural sources [1,2]. Herbal-based drug delivery systems have long been used in folk medicine, and herbal medicines of natural origin show good therapeutic activity with minimal side effects.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Sonneratia Alba Leaf Extract Microcapsules by Solvent Evaporation Technique

et al. 2022

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Objective: Sonneratia alba leaves were used by the community for traditional medicine to cure muscle pain, back pain, antioxidants, rheumatism, malaria, wounds, tuberculosis (TB) and as a spermicide. S. alba leaves extract was easy to damage because of the light exposure, change of pH, weather and a long period of storage time. The problem can be solved by coating the extract with a microencapsulation technique. The purpose of this research was to formulate the microcapsules of S. alba leaves extract with solvent evaporation technique using Ethocel 10 cP and Eudragit E100 as a matrix. Methods: S. alba leaves were extracted using ethanol 96%. This extract was dried by a rotary evaporator. The microencapsulation process of S. alba leaves extract was done by solvent evaporation technique (O/W: oil in water). The formula of S. alba leaves extract microcapsules was designed into six formulas (Eudragit E100: EA1, EA2, EA3 and Ethocel 10 cP: EB1, EB2, EB3). Microcapsules of S. alba leaves extract were characterized for particle size in terms of surface morphology by scanning electron microscope (SEM) and encapsulation efficiency. Antioxidant activity of the formulation have been evaluated by DPPH method. Physical characterization on microparticles was performed by conducting entrapment efficiency and SEM picture. Results: In this research, the microparticles containing S. alba extract has been developed by using ethyl cellulose (Ethocel 10 cP) and eudragit (Eudragit E100) as the polymer matrix. The results showed that a high concentration of polymer (Ethocel 10 cP and Eudragit E100) used in microencapsulation resulted in better S. alba leaves extract microcapsules in terms of physical characteristics. Particle size of microcapsules containing S. alba leaves extract were in the range of 0.701 to 1.163 μm. Encapsulation efficiency (% EE) was categorized as poor because the value were ≤ 80% to which 74.386% (EB3) and 75.248% (EA1). SEM picture of EA1 (Eudragit E100) revealed that the surface of microcapsule were rough and porous. When Ethocel 10 cP was used as a polymer, a smoother surface and less visible pores of microcapsule were obtained. The antioxidant ability of S. alba leaves extract microcapsule showed that IC50 values were 53.26 ppm. Conclusion: It can be concluded that microcapsules of S. alba leaves extract can be prepared by solvent evaporation technique using Eudragit E100 and Ethocel 10 cP as polymer. S. alba leaves has potent antioxidant activity either as an extract or after being formulated into microcapsules.

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Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Sonneratia Alba Leaf Extract Microcapsules by Solvent Evaporation Technique

et al. 2022

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“…The resulting release rate(s) of the integrated drug(s) was/were determined to be regulated over at least 28 d in all situations. Furthermore, carbamazepine release was often slower than propranolol HCl release, which can most likely be due to carbamazepine's significantly lower solubility in the release medium (0.2 mg/ml vs. 250 mg/ml), resulting in lesser concentration gradients, which are the major factors for diffusion [24,[29][30][31][32][33][34][35]. The integration of carbamazepine on the surface of propranolol HCl loaded microparticles may explain the increased carbamazepine release from microparticle blends with the W/O/W (Pro) and O/W (CBZ) (DTI 60 min).…”

Section: Release Of Propranolol Hcl and Carbamazepine From Microparti...mentioning

confidence: 99%

Preparation and Evaluation of Propranolol HCL and Carbamazepine Release Profiles From Poly(є-Caprolactone) Microparticle Blends System

MUHAIMIN,

CHAERUNISAA,

HAZRINA

2023

Int J App Pharm

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Objective: The goal of this research was to look into the physicochemical properties of poly(-caprolactone) microparticle blends that contained medicines of various solubilities (Propranolol HCl [Pro] and carbamazepine [CBZ]). Methods: W/O/W emulsion for Pro and O/W emulsion for CBZ were used to create microparticle blends. With dispersion time intervals (DTI) of 0 and 60 min, the Pro emulsion (W/O) and CBZ oil phase (O) were dispersed in an external aqueous phase (W). Scanning electron microscopy was used to examine the morphology of microparticle blends (SEM). Focused beam reflectance measurements were utilized to monitor the particle size mean of emulsion droplets/hardened microparticles (FBRM). In phosphate buffer (pH 7.4), encapsulation efficiency (EE) and in vitro drug release were also examined. Results: The final microparticle blends generated by solvent evaporation method were spherical and had two populations, according to the findings. The size of microparticle blends prepared with DTI 60 min and stirring duration 4 h was bigger than those prepared with DTI 0 min, according to FBRM data. In microparticle blends, encapsulation efficiency ranged from 62.05±3.74 percent to 66.38±4.16 percent for Pro and 70.56±4.62 percent to 73.85±4.11 percent for CBZ. After 28 d, drug release in phosphate buffer revealed that Pro release (33%) was shorter than CBZ release (60%) from microparticle blends with DTI 60 min. This was related to the interaction of the oil phase (CBZ) with hard particles from the primary emulsion (Pro), in which the oil phase occluded and covered surface structure of the harsh particles from the primary emulsion. Conclusion: Novel microparticle blends comprising drugs/medicines with varying solubilities (e. g. propranolol HCl and carbamazepine) have a lot of promise as controlled-release drug delivery systems. The physical properties of microparticle blends were impacted by the type of dispersion time interval used.

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Polymer Type Effect on Premna Serratifolia Extract-Loaded Microparticles Preparation by Solvent Evaporation Method With Single Emulsion System

NURHASANAH,

ISKANDAR,

MUHAIMIN

et al. 2024

Int J App Pharm

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Objective: Premna serratifolia linn leaf possesses medicinal properties, useful in the treatment of cardiovascular diseases, skin diseases, inflammatory diseases and arthritis. P. serratifolia leaves extract was easy to damage because the light exposure, change of pH, weather and a long period of storage time. The problem can be solved by preparation the extract with microparticle technique. The purpose of this research was to formulate the microparticles of P. serratifolia leaves extract with solvent evaporation technique using Ethocel 10 cP and Eudragit E100 as matrix. Methods: P. serratifolia leaves were extracted using ethanol 70%. This extract was dried by rotary evaporator. The microparticle process of P. serratifolia leaves extract was done by solvent evaporation technique (O/W: oil in water). The formula of P. serratifolia leaves extract microparticles was designed into six formulas (Ethocel 10 cP: EA1, EA2, EA3 and Eudragit E100: EB1, EB2, EB3 (10%,15%, 20%)), that they were dissolved in dichloromethane. Microparticles of P. serratifolia leaves extract were characterized for particle size in terms of surface morphology by scanning electron microscope (SEM) and encapsulation efficiency. Results: In this research, the micoparticles containing P. serratifolia extract has been developed by using ethyl cellulose (Ethocel 10 cP) and eudragit (Eudragit E100) as the polymer matrix. The results showed that high concentration of polymer (Ethocel 10 cP (20%)) used in microparticles resulted in better P. serratifolia leaves extract microparticles in terms of physical characteristics. Particle size of microparticles containing P. serratifolia leaves extract were in the range of 1.024 to 1.662 μm. Encapsulation efficiency (% EE) was categorized as good because the value were ≥ 80% to, which 83.101% (EB3) and 85.574% (EA3). SEM picture of EA3 (Ethocel 10 cP) revealed that the surface of microparticles were a smoother surface and less visible pores of microparticles were obtained. When Eudragit E100 used as polymer, a rough and porous surface of microparticles were obtained. Conclusion: It can be concluded that microparticles of P. serratifolia leaves extract can be prepared by solvent evaporation method with a single emulsion system (O/W) using Ethocel 10 cP and Eudragit E100 as polymer. Characterization of the microparticles revealed that polymer type used on this method is applicable to produce microparticles.

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Designing of Novel Topical in Situ Polymeric Film-Forming Solution Spray Formulation of Antifungal Agent: In Vitro Activity and in Vivo Characterization

Cited by 4 publications

References 33 publications

Preparation and Characterization of Sonneratia Alba Leaf Extract Microcapsules by Solvent Evaporation Technique

Preparation and Characterization of Sonneratia Alba Leaf Extract Microcapsules by Solvent Evaporation Technique

Preparation and Evaluation of Propranolol HCL and Carbamazepine Release Profiles From Poly(є-Caprolactone) Microparticle Blends System

Polymer Type Effect on Premna Serratifolia Extract-Loaded Microparticles Preparation by Solvent Evaporation Method With Single Emulsion System

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