Designing Peptide Drugs/Ligands for Pathological States. A New Paradigm for Design of Bioactive Peptide Hormones and Neurotransmitters

Hruby, Victor J.; Agnes, Richard S.; Lee, Yeon‐Sun; Davis, Peg; Ma, Shou-Wu; Lai, Josephine; Porreca, Frank

doi:10.1007/978-94-010-0464-0_452

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Development Of a Robust Strategy For Ligand-based Peptide De...1

Conformational Constraint the Ramachandran Plot And Design O...1

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Cited by 4 publications

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“…We have taken neuropathic pain, for which there are no currently effective drugs, as an example. 161,162 Though we are in the early stages of development, we have made significant progress, enough to warrant a few paragraphs of discussion.…”

Section: Development Of a Robust Strategy For Ligand-based Peptide De...mentioning

confidence: 99%

“…We have initiated studies to face this new reality directly and to design molecules (ligands, potential drugs) that are designed specifically for the disease state. We have taken neuropathic pain, for which there are no currently effective drugs, as an example. , Though we are in the early stages of development, we have made significant progress, enough to warrant a few paragraphs of discussion.

9 Drug design approaches. …”

Section: Conformational Constraint the Ramachandran Plot And Design O...mentioning

confidence: 99%

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